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Synergistic cytotoxic effects of antibodies directed against different cell surface determinants

Journal Article:

Abstract

Three antibody populations were raised in rabbits against surface antigens on guinea-pig L/sub 2/C leukaemic lymphocytes: against idiotypic determinants on the lambda chain of the surface immunoglobulin, against C region determinants on the lambda chain, and against the surface antigens recognised by conventional anti-lymphocyte sera. Complement and K-cell cytotoxicities effected by the antibodies on L/sub 2/C cells were studied in vitro. In both cytotoxic systems mixtures of the antibodies revealed synergy, in that the titres of the mixtures exceeded predicted additive titres of their components. The synergy was greater when the mixed antibodies were directed to determinants on the same molecule rather than to determinants on different molecules.
Authors:
Elliott, E V; Pindar, A; Stevenson, F K; Stevenson, G T [1] 
  1. Southampton General Hospital (UK). Tenovus Research Lab.
Publication Date:
Mar 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-09-386189; EDB-78-098601
Resource Relation:
Journal Name: Immunology; (United Kingdom); Journal Volume: 34:3
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIGEN-ANTIBODY REACTIONS; COMPARATIVE EVALUATIONS; ANTIBODIES; CELL KILLING; CHROMIUM 51; IMMUNE SERUMS; IMMUNOGLOBULINS; IN VITRO; LEUKEMIA; LYMPHOCYTES; RADIO-RELEASE ANALYSIS; SYNERGISM; TRACER TECHNIQUES; TUMOR CELLS; ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHEMICAL ANALYSIS; CHROMIUM ISOTOPES; CONNECTIVE TISSUE CELLS; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; GLOBULINS; HEMIC DISEASES; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; LEUKOCYTES; NEOPLASMS; NUCLEI; ORGANIC COMPOUNDS; PROTEINS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOISOTOPES; SOMATIC CELLS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
7057632
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IMMUA
Submitting Site:
INIS
Size:
Pages: 405-409
Announcement Date:
Jul 01, 1978

Journal Article:

Citation Formats

Elliott, E V, Pindar, A, Stevenson, F K, and Stevenson, G T. Synergistic cytotoxic effects of antibodies directed against different cell surface determinants. United Kingdom: N. p., 1978. Web.
Elliott, E V, Pindar, A, Stevenson, F K, & Stevenson, G T. Synergistic cytotoxic effects of antibodies directed against different cell surface determinants. United Kingdom.
Elliott, E V, Pindar, A, Stevenson, F K, and Stevenson, G T. 1978. "Synergistic cytotoxic effects of antibodies directed against different cell surface determinants." United Kingdom.
@misc{etde_7057632,
title = {Synergistic cytotoxic effects of antibodies directed against different cell surface determinants}
author = {Elliott, E V, Pindar, A, Stevenson, F K, and Stevenson, G T}
abstractNote = {Three antibody populations were raised in rabbits against surface antigens on guinea-pig L/sub 2/C leukaemic lymphocytes: against idiotypic determinants on the lambda chain of the surface immunoglobulin, against C region determinants on the lambda chain, and against the surface antigens recognised by conventional anti-lymphocyte sera. Complement and K-cell cytotoxicities effected by the antibodies on L/sub 2/C cells were studied in vitro. In both cytotoxic systems mixtures of the antibodies revealed synergy, in that the titres of the mixtures exceeded predicted additive titres of their components. The synergy was greater when the mixed antibodies were directed to determinants on the same molecule rather than to determinants on different molecules.}
journal = {Immunology; (United Kingdom)}
volume = {34:3}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Mar}
}