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/sup 67/Ga-binding substances in abscess and normal tissues

Journal Article:

Abstract

Abscess-induced animals and normal animals were treated with /sup 67/Ga-citrate. Abscess, kidney, heart, lung, and spleen were excised and homogenized. After removal of the nuclear fraction, each of these homogenates was digested with protease. After digestion, the supernatants of the reaction mixtures were applied to a Sephadex G-100 column. Resultant eluates were analyzed for radioactivity, protein, uronic acids, and sialic acids. Sodium sulfate-/sup 35/S was administered to animals that were then treated by the same procedure as that followed for animals treated with /sup 67/Ga-citrate. In abscess, kidney, lung, heart, and spleen, sizeable amounts of /sup 67/Ga had been bound to the sulfated acid mucopolysaccharides with molecular weights of about 10,000, and to the sulfated acid mucopolysaccharides, a species whole molecular weights exceeded 40,000. Based on the results presented here, it is clear that /sup 67/Ga-binding substances in abscess and also in the above four organs are sulfated acid mucopolysaccharides.
Publication Date:
Jul 01, 1984
Product Type:
Journal Article
Reference Number:
FRG-84-08350; EDB-84-111380
Resource Relation:
Journal Name: Eur. J. Nucl. Med.; (Germany, Federal Republic of); Journal Volume: 9:7
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GALLIUM 67; ABSCESSES; TISSUES; CHEMICAL REACTIONS; CITRATES; GALLIUM COMPOUNDS; HEART; HOMOGENATES; KIDNEYS; LABELLED COMPOUNDS; LUNGS; MUCOPOLYSACCHARIDES; RADIOPHARMACEUTICALS; RATS; SODIUM SULFATES; SPLEEN; ALKALI METAL COMPOUNDS; AMINES; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARBOXYLIC ACID SALTS; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GALLIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PATHOLOGICAL CHANGES; POLYSACCHARIDES; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; SACCHARIDES; SODIUM COMPOUNDS; SULFATES; SULFUR COMPOUNDS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
OSTI ID:
7056178
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJNMD
Submitting Site:
HEDB
Size:
Pages: 300-304
Announcement Date:
Jul 01, 1984

Journal Article:

Citation Formats

Ando, A, Ando, I, Hiraki, T, Hisada, K, Nitta, K, and Ogawa, H. /sup 67/Ga-binding substances in abscess and normal tissues. Germany: N. p., 1984. Web.
Ando, A, Ando, I, Hiraki, T, Hisada, K, Nitta, K, & Ogawa, H. /sup 67/Ga-binding substances in abscess and normal tissues. Germany.
Ando, A, Ando, I, Hiraki, T, Hisada, K, Nitta, K, and Ogawa, H. 1984. "/sup 67/Ga-binding substances in abscess and normal tissues." Germany.
@misc{etde_7056178,
title = {/sup 67/Ga-binding substances in abscess and normal tissues}
author = {Ando, A, Ando, I, Hiraki, T, Hisada, K, Nitta, K, and Ogawa, H}
abstractNote = {Abscess-induced animals and normal animals were treated with /sup 67/Ga-citrate. Abscess, kidney, heart, lung, and spleen were excised and homogenized. After removal of the nuclear fraction, each of these homogenates was digested with protease. After digestion, the supernatants of the reaction mixtures were applied to a Sephadex G-100 column. Resultant eluates were analyzed for radioactivity, protein, uronic acids, and sialic acids. Sodium sulfate-/sup 35/S was administered to animals that were then treated by the same procedure as that followed for animals treated with /sup 67/Ga-citrate. In abscess, kidney, lung, heart, and spleen, sizeable amounts of /sup 67/Ga had been bound to the sulfated acid mucopolysaccharides with molecular weights of about 10,000, and to the sulfated acid mucopolysaccharides, a species whole molecular weights exceeded 40,000. Based on the results presented here, it is clear that /sup 67/Ga-binding substances in abscess and also in the above four organs are sulfated acid mucopolysaccharides.}
journal = {Eur. J. Nucl. Med.; (Germany, Federal Republic of)}
volume = {9:7}
journal type = {AC}
place = {Germany}
year = {1984}
month = {Jul}
}