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Whole-body retention studies of /sup 169/Yb-citrate. Estimation of radiation dose to humans from /sup 169/Yb-citrate

Journal Article:

Abstract

For purpose of the estimation of the radiation dose to humans from /sup 169/Yb-citrate, the whole-body retention studies using five rats were carried out. Following intravenous administration of /sup 169/Yb-citrate, the whole-body activity was monitored for 40 days by the animal counter. The whole-body retention curve consisted of three components: the first with a 3.6 hours effective half-time, the second with an 154 hours effective half-time and the third with a 29.9 days effective half-time. Therefore it was assumed that 32% of the administered /sup 169/Yb-citrate clears from the kidney with a short biologic half-time (3.6 hours), 18% remains in the liver and other soft tissues with a relatively long biologic half-time (194 hours) and 50% remains in the bone with a long biologic half-time (850 days). Based on these biological data and the MIRD Committee method, the average dose to the bone and whole-body were 20.8 rads/mCi and 4.5 rads/mCi respectively.
Authors:
Ando, A; Hiraki, T; [1]  Mori, H; Ando, I; Hisada, K
  1. Kanazawa Univ. (Japan). School of Paramedicine
Publication Date:
Sep 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-379088; EDB-78-098921
Resource Relation:
Journal Name: Radioisotopes (Tokyo); (Japan); Journal Volume: 26:9
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; KIDNEYS; RETENTION FUNCTIONS; LIVER; MAN; RADIATION DOSES; RATS; RADIONUCLIDE KINETICS; SKELETON; YTTERBIUM 169; BIOLOGICAL HALF-LIFE; RETENTION; CITRATES; EXCRETION; INTERNAL IRRADIATION; RADIOPHARMACEUTICALS; TIME DEPENDENCE; URINE; WHOLE-BODY COUNTING; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CARBOXYLIC ACID SALTS; CLEARANCE; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DOSES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; GLANDS; INTERMEDIATE MASS NUCLEI; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RARE EARTH ISOTOPES; RARE EARTH NUCLEI; RODENTS; VERTEBRATES; WASTES; YTTERBIUM ISOTOPES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man
OSTI ID:
7055980
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: RAISA
Submitting Site:
INIS
Size:
Pages: 602-605
Announcement Date:
Jul 01, 1978

Journal Article:

Citation Formats

Ando, A, Hiraki, T, Mori, H, Ando, I, and Hisada, K. Whole-body retention studies of /sup 169/Yb-citrate. Estimation of radiation dose to humans from /sup 169/Yb-citrate. Japan: N. p., 1977. Web.
Ando, A, Hiraki, T, Mori, H, Ando, I, & Hisada, K. Whole-body retention studies of /sup 169/Yb-citrate. Estimation of radiation dose to humans from /sup 169/Yb-citrate. Japan.
Ando, A, Hiraki, T, Mori, H, Ando, I, and Hisada, K. 1977. "Whole-body retention studies of /sup 169/Yb-citrate. Estimation of radiation dose to humans from /sup 169/Yb-citrate." Japan.
@misc{etde_7055980,
title = {Whole-body retention studies of /sup 169/Yb-citrate. Estimation of radiation dose to humans from /sup 169/Yb-citrate}
author = {Ando, A, Hiraki, T, Mori, H, Ando, I, and Hisada, K}
abstractNote = {For purpose of the estimation of the radiation dose to humans from /sup 169/Yb-citrate, the whole-body retention studies using five rats were carried out. Following intravenous administration of /sup 169/Yb-citrate, the whole-body activity was monitored for 40 days by the animal counter. The whole-body retention curve consisted of three components: the first with a 3.6 hours effective half-time, the second with an 154 hours effective half-time and the third with a 29.9 days effective half-time. Therefore it was assumed that 32% of the administered /sup 169/Yb-citrate clears from the kidney with a short biologic half-time (3.6 hours), 18% remains in the liver and other soft tissues with a relatively long biologic half-time (194 hours) and 50% remains in the bone with a long biologic half-time (850 days). Based on these biological data and the MIRD Committee method, the average dose to the bone and whole-body were 20.8 rads/mCi and 4.5 rads/mCi respectively.}
journal = {Radioisotopes (Tokyo); (Japan)}
volume = {26:9}
journal type = {AC}
place = {Japan}
year = {1977}
month = {Sep}
}