You need JavaScript to view this

Experimental study of the preventional effects of drugs to lung radiation damage

Journal Article:

Abstract

The author experimented on effects of Cepharanthin (CR) and Urokinase (UK) on the lung of rabbits to which /sup 60/Co was irradiated by dividing a total dose of 10,000R into 500R a day. The rabbits irradiated were divided into 3 groups: a group administered ''CR'' (Group A), a group administered ''UK'' (Group B) and a control group (Group C). Body weight, leukocytes and chest x-ray findings were examined, and macroscopic and microscopic findings were discussed immediately and 3 months after irradiation. CR was effective in preventing the decrease of leukocytes and body weight. In the case of 5000R irradiation, an abnormal shadow was not recognized, but in the case of 10,000R irradiation, radiation pneumonitis began to appear immediately after the irradiation, and heart dilation and the shift of mediastinum on the side of irradiation were observed 3 months after that. In Group C, adhesion, hydropericardium and bleeding lesion were observed. In Groups A and B, the preventive effects were noted macroscopically. Group A seemed to show more significant results. In this group, the infiltration of the cells, and the appearance of foamy cells and eosinophyl cells which are characteristic of lung radiation disease were less observed than those in the  More>>
Authors:
Tomita, N [1] 
  1. Kurume Univ., Fukuoka (Japan). School of Medicine
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-391712; EDB-78-117839
Resource Relation:
Journal Name: Igaku Kenkyu; (Japan); Journal Volume: 47:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GAMMA RADIATION; BIOLOGICAL RADIATION EFFECTS; LUNGS; MORPHOLOGICAL CHANGES; RADIOPROTECTIVE SUBSTANCES; UROKINASE; ALKALOIDS; BLOOD VESSELS; CHEMOTHERAPY; INFLAMMATION; IRRADIATION; LEUKOCYTES; RABBITS; RADIATION PROTECTION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; ENZYMES; HYDROLASES; IONIZING RADIATIONS; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PEPTIDE HYDROLASES; RADIATION EFFECTS; RADIATIONS; RESPIRATORY SYSTEM; RESPONSE MODIFYING FACTORS; THERAPY; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7052670
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: IGKEA
Submitting Site:
INIS
Size:
Pages: 1-11
Announcement Date:
Sep 01, 1978

Journal Article:

Citation Formats

Tomita, N. Experimental study of the preventional effects of drugs to lung radiation damage. Japan: N. p., 1977. Web.
Tomita, N. Experimental study of the preventional effects of drugs to lung radiation damage. Japan.
Tomita, N. 1977. "Experimental study of the preventional effects of drugs to lung radiation damage." Japan.
@misc{etde_7052670,
title = {Experimental study of the preventional effects of drugs to lung radiation damage}
author = {Tomita, N}
abstractNote = {The author experimented on effects of Cepharanthin (CR) and Urokinase (UK) on the lung of rabbits to which /sup 60/Co was irradiated by dividing a total dose of 10,000R into 500R a day. The rabbits irradiated were divided into 3 groups: a group administered ''CR'' (Group A), a group administered ''UK'' (Group B) and a control group (Group C). Body weight, leukocytes and chest x-ray findings were examined, and macroscopic and microscopic findings were discussed immediately and 3 months after irradiation. CR was effective in preventing the decrease of leukocytes and body weight. In the case of 5000R irradiation, an abnormal shadow was not recognized, but in the case of 10,000R irradiation, radiation pneumonitis began to appear immediately after the irradiation, and heart dilation and the shift of mediastinum on the side of irradiation were observed 3 months after that. In Group C, adhesion, hydropericardium and bleeding lesion were observed. In Groups A and B, the preventive effects were noted macroscopically. Group A seemed to show more significant results. In this group, the infiltration of the cells, and the appearance of foamy cells and eosinophyl cells which are characteristic of lung radiation disease were less observed than those in the other groups, and therefore, Group A showed more preventive effect upon inflammation than the other groups. In Group B, the thickness of the wall of the blood vessel tended to be improved 3 months after irradiation. Microthrombosis was not recognized, either. From these results, CR was effective in decreasing the infiltration of the cells, and UK was effective in decreasing the thickness of the wall of the blood vessel and in forming thromboses. Thus, these drugs should be used simultaneously because they had different reaction to the prevention of lung radiation disease.}
journal = {Igaku Kenkyu; (Japan)}
volume = {47:1}
journal type = {AC}
place = {Japan}
year = {1977}
month = {Jan}
}