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Localization of ( sup 18 F)fluorodeoxyglucose in mouse brain neurons with micro-autoradiography

Abstract

This is the first study of micro-autoradiography (micro-ARG) for ({sup 18}F)2-fluoro-2-deoxy-D-glucose (({sup 18}F)FDG). The localization of ({sup 18}F)FDG was demonstrated in dendrites of neuron and also in the myelinated axon in mouse normal brain in vivo. The nucleolus was relatively free of label. The counted silver grain numbers in autoradiogram were linearly correlated to the {sup 18}F radioactivities in the specimen. The micro-ARG using positron emitting {sup 18}F is a very time-saving technique with 4 hours exposure compared with the conventional method using {sup 3}H- or {sup 14}C-labelled tracers. (author).
Authors:
Yamada, Susumu; Kubota, Roko; Kubota, Kazuo; [1]  Ishiwata, Kiichi; Ido, Tatsuo [2] 
  1. Department of Radiology and Nuclear Medicine, The Research Institute for Tuberculosis and Cancer (Japan)
  2. Tohoku Univ., Sendai (Japan). Cyclotron and Radioisotope Center
Publication Date:
Dec 11, 1990
Product Type:
Journal Article
Reference Number:
AIX-23-062986; EDB-92-136669
Resource Relation:
Journal Name: Neuroscience Letters; (Ireland); Journal Volume: 120:2
Subject:
60 APPLIED LIFE SCIENCES; FLUORODEOXYGLUCOSE; AUTORADIOGRAPHY; FLUORINE 18; IMAGES; LABELLING; MYELIN; NERVE CELLS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; TRACER TECHNIQUES; ANIMAL CELLS; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CELL CONSTITUENTS; CELL MEMBRANES; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MEMBRANES; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; SOMATIC CELLS; TOMOGRAPHY; 553005* - Agriculture & Food Technology- Animal Husbandry- (1987-)
OSTI ID:
7044883
Country of Origin:
Ireland
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0304-3940; CODEN: NELED
Submitting Site:
INIS
Size:
Pages: 191-193
Announcement Date:

Citation Formats

Yamada, Susumu, Kubota, Roko, Kubota, Kazuo, Ishiwata, Kiichi, and Ido, Tatsuo. Localization of ( sup 18 F)fluorodeoxyglucose in mouse brain neurons with micro-autoradiography. Ireland: N. p., 1990. Web. doi:10.1016/0304-3940(90)90035-8.
Yamada, Susumu, Kubota, Roko, Kubota, Kazuo, Ishiwata, Kiichi, & Ido, Tatsuo. Localization of ( sup 18 F)fluorodeoxyglucose in mouse brain neurons with micro-autoradiography. Ireland. doi:10.1016/0304-3940(90)90035-8.
Yamada, Susumu, Kubota, Roko, Kubota, Kazuo, Ishiwata, Kiichi, and Ido, Tatsuo. 1990. "Localization of ( sup 18 F)fluorodeoxyglucose in mouse brain neurons with micro-autoradiography." Ireland. doi:10.1016/0304-3940(90)90035-8. https://www.osti.gov/servlets/purl/10.1016/0304-3940(90)90035-8.
@misc{etde_7044883,
title = {Localization of ( sup 18 F)fluorodeoxyglucose in mouse brain neurons with micro-autoradiography}
author = {Yamada, Susumu, Kubota, Roko, Kubota, Kazuo, Ishiwata, Kiichi, and Ido, Tatsuo}
abstractNote = {This is the first study of micro-autoradiography (micro-ARG) for ({sup 18}F)2-fluoro-2-deoxy-D-glucose (({sup 18}F)FDG). The localization of ({sup 18}F)FDG was demonstrated in dendrites of neuron and also in the myelinated axon in mouse normal brain in vivo. The nucleolus was relatively free of label. The counted silver grain numbers in autoradiogram were linearly correlated to the {sup 18}F radioactivities in the specimen. The micro-ARG using positron emitting {sup 18}F is a very time-saving technique with 4 hours exposure compared with the conventional method using {sup 3}H- or {sup 14}C-labelled tracers. (author).}
doi = {10.1016/0304-3940(90)90035-8}
journal = {Neuroscience Letters; (Ireland)}
volume = {120:2}
journal type = {AC}
place = {Ireland}
year = {1990}
month = {Dec}
}