Abstract
The pharmacokinetic parameters of GM1 ganglioside were examined in 16 patients (mean age 64 {plus minus} 5 years) with Alzheimer's disease. The ganglioside was given intramuscularly and subcutaneously. The maximum GM1 blood level was reached after 48-72 h, the subcutaneous route leading to the highest blood levels, but the individual variability was relatively large. When 100 mg GM1 ganglioside was given daily for a week, maximum serum values of 15 to 20 {sup m}u{sup m}ol/l were found in 3 patients. The elimination half-life from serum was 60-75 h. (author).
Svennerholm, L;
Gottfries, C G;
Blennow, K;
Fredman, P;
Karlsson, I;
Maansson, J -E;
[1]
Toffano, G;
Wallin, A
[2]
- Department of Psychiatry and Neurochemistry, Gothenburg University (Sweden)
- Fidia Research Laboratories, Abano Terme (Italy)
Citation Formats
Svennerholm, L, Gottfries, C G, Blennow, K, Fredman, P, Karlsson, I, Maansson, J -E, Toffano, G, and Wallin, A.
Parenteral administration of GM1 ganglioside to presenile Alzheimer patients.
Denmark: N. p.,
1990.
Web.
Svennerholm, L, Gottfries, C G, Blennow, K, Fredman, P, Karlsson, I, Maansson, J -E, Toffano, G, & Wallin, A.
Parenteral administration of GM1 ganglioside to presenile Alzheimer patients.
Denmark.
Svennerholm, L, Gottfries, C G, Blennow, K, Fredman, P, Karlsson, I, Maansson, J -E, Toffano, G, and Wallin, A.
1990.
"Parenteral administration of GM1 ganglioside to presenile Alzheimer patients."
Denmark.
@misc{etde_7043052,
title = {Parenteral administration of GM1 ganglioside to presenile Alzheimer patients}
author = {Svennerholm, L, Gottfries, C G, Blennow, K, Fredman, P, Karlsson, I, Maansson, J -E, Toffano, G, and Wallin, A}
abstractNote = {The pharmacokinetic parameters of GM1 ganglioside were examined in 16 patients (mean age 64 {plus minus} 5 years) with Alzheimer's disease. The ganglioside was given intramuscularly and subcutaneously. The maximum GM1 blood level was reached after 48-72 h, the subcutaneous route leading to the highest blood levels, but the individual variability was relatively large. When 100 mg GM1 ganglioside was given daily for a week, maximum serum values of 15 to 20 {sup m}u{sup m}ol/l were found in 3 patients. The elimination half-life from serum was 60-75 h. (author).}
journal = []
volume = {81}
journal type = {AC}
place = {Denmark}
year = {1990}
month = {Jan}
}
title = {Parenteral administration of GM1 ganglioside to presenile Alzheimer patients}
author = {Svennerholm, L, Gottfries, C G, Blennow, K, Fredman, P, Karlsson, I, Maansson, J -E, Toffano, G, and Wallin, A}
abstractNote = {The pharmacokinetic parameters of GM1 ganglioside were examined in 16 patients (mean age 64 {plus minus} 5 years) with Alzheimer's disease. The ganglioside was given intramuscularly and subcutaneously. The maximum GM1 blood level was reached after 48-72 h, the subcutaneous route leading to the highest blood levels, but the individual variability was relatively large. When 100 mg GM1 ganglioside was given daily for a week, maximum serum values of 15 to 20 {sup m}u{sup m}ol/l were found in 3 patients. The elimination half-life from serum was 60-75 h. (author).}
journal = []
volume = {81}
journal type = {AC}
place = {Denmark}
year = {1990}
month = {Jan}
}