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Positron emission tomography in degenerative disorders of the dopaminergic system

Journal Article:

Abstract

21 patients who had Parkinson's disease (PD), PD plus dementia of Alzheimer type (PDAT) or progressive supranuclear palsy (PSP), were studied with positron emission tomography (PET) using ({sup 18}F)-2-fluoro-2-deoxy-D-glucose (FDG). In one patient with strictly unilateral PD side differences in striatal dopa uptake were studied with 6-({sup 18}F)fluoro-L-dopa (F-dopa). In patients with PD PET with FDG did not show any significant change in regional cerebral metabolic rates for glucose (rCMR(Glu)). In PDAT glucose metabolism was generally reduced, the most severe decrease was found in parietal cortex. The metabolic pattern was similar to that typically found in patients with Alzheimer's disease (AD). In the patient with strictly unilateral PD rCMR(Glu) was normal, F-dopa PET, however, revealed a distinct reduction of dopa uptake in the contralateral putamen. In PSP glucose metabolism was significantly decreased in subcortical regions (caudatum, putamen and brainstem) and in frontal cortex. Thus PET demonstrated a clear difference of metabolic pattern between PDAT and PSP. (authors).
Authors:
Karbe, H; Holthoff, V; Huber, M; Herholz, K; Wienhard, K; Wagner, R; Heiss, W D [1] 
  1. Universitaetsklinik fuer Neurologie und Max-Planck-Institut fuer neurologische Forschung, Koeln (Germany)
Publication Date:
Jan 01, 1992
Product Type:
Journal Article
Reference Number:
AIX-23-086784; EDB-92-181214
Resource Relation:
Journal Name: Journal of Neural Transmission; (Austria); Journal Volume: 4:2,Parkinson's Disease and Dementia Section
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; POSITRON COMPUTED TOMOGRAPHY; BRAIN; DOPAMINE; GLUCOSE; PATIENTS; ALDEHYDES; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CARBOHYDRATES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; HEXOSES; HYDROXY COMPOUNDS; MONOSACCHARIDES; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; SACCHARIDES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
7033619
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0300-9564; CODEN: JNTMA
Submitting Site:
INIS
Size:
Pages: 121-130
Announcement Date:
Dec 15, 1992

Journal Article:

Citation Formats

Karbe, H, Holthoff, V, Huber, M, Herholz, K, Wienhard, K, Wagner, R, and Heiss, W D. Positron emission tomography in degenerative disorders of the dopaminergic system. Austria: N. p., 1992. Web.
Karbe, H, Holthoff, V, Huber, M, Herholz, K, Wienhard, K, Wagner, R, & Heiss, W D. Positron emission tomography in degenerative disorders of the dopaminergic system. Austria.
Karbe, H, Holthoff, V, Huber, M, Herholz, K, Wienhard, K, Wagner, R, and Heiss, W D. 1992. "Positron emission tomography in degenerative disorders of the dopaminergic system." Austria.
@misc{etde_7033619,
title = {Positron emission tomography in degenerative disorders of the dopaminergic system}
author = {Karbe, H, Holthoff, V, Huber, M, Herholz, K, Wienhard, K, Wagner, R, and Heiss, W D}
abstractNote = {21 patients who had Parkinson's disease (PD), PD plus dementia of Alzheimer type (PDAT) or progressive supranuclear palsy (PSP), were studied with positron emission tomography (PET) using ({sup 18}F)-2-fluoro-2-deoxy-D-glucose (FDG). In one patient with strictly unilateral PD side differences in striatal dopa uptake were studied with 6-({sup 18}F)fluoro-L-dopa (F-dopa). In patients with PD PET with FDG did not show any significant change in regional cerebral metabolic rates for glucose (rCMR(Glu)). In PDAT glucose metabolism was generally reduced, the most severe decrease was found in parietal cortex. The metabolic pattern was similar to that typically found in patients with Alzheimer's disease (AD). In the patient with strictly unilateral PD rCMR(Glu) was normal, F-dopa PET, however, revealed a distinct reduction of dopa uptake in the contralateral putamen. In PSP glucose metabolism was significantly decreased in subcortical regions (caudatum, putamen and brainstem) and in frontal cortex. Thus PET demonstrated a clear difference of metabolic pattern between PDAT and PSP. (authors).}
journal = {Journal of Neural Transmission; (Austria)}
volume = {4:2,Parkinson's Disease and Dementia Section}
journal type = {AC}
place = {Austria}
year = {1992}
month = {Jan}
}