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Quantitative changes in the cellularity of the rat subependymal plate after X-irradiation

Journal Article:

Abstract

The brains of young adult rats were irradiated with a single dose of 8 Gy (800 rad) of 250 kVp X-rays. Within 2 weeks of treatment the cell population of the subependymal plate was reduced by 30%. During this period the cell cycle time remained unchanged but the labelling index was reduced. The cell population subsequently returned to normal after 39-52 weeks. Damage and subsequent recovery of the plate was due mainly to changes in the number of cells with small dark nuclei. Cells with small and large light nuclei were little affected. A model for the production and differentiation of cells in the subependymal region is proposed on the basis of age-related changes in the total number and proportions of the various cell types in the subependymal plate of normal rats. This is discussed both in terms of the radiation response of cells in the plate and the manifestation of delayed white matter necrosis after higher doses.
Authors:
Hubbard, B; Hopewell, J W [1] 
  1. Oxford Univ. (UK). Churchill Hospital Research Institute
Publication Date:
Jul 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-11-570045; EDB-81-012932
Resource Relation:
Journal Name: Cell Tissue Kinet.; (United Kingdom); Journal Volume: 13:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BRAIN; RADIOSENSITIVITY; CELL PROLIFERATION; RADIATION INJURIES; ACUTE IRRADIATION; AGE DEPENDENCE; CELL CYCLE; CELL NUCLEI; RATS; SUBLETHAL IRRADIATION; X RADIATION; ACUTE EXPOSURE; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CELL CONSTITUENTS; CENTRAL NERVOUS SYSTEM; ELECTROMAGNETIC RADIATION; INJURIES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NERVOUS SYSTEM; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 560114 - Radiation Effects on Biochemicals- In Animals- (-1987)
OSTI ID:
7029035
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CTKIA
Submitting Site:
INIS
Size:
Pages: 403-413
Announcement Date:
Jan 01, 1981

Journal Article:

Citation Formats

Hubbard, B, and Hopewell, J W. Quantitative changes in the cellularity of the rat subependymal plate after X-irradiation. United Kingdom: N. p., 1980. Web.
Hubbard, B, & Hopewell, J W. Quantitative changes in the cellularity of the rat subependymal plate after X-irradiation. United Kingdom.
Hubbard, B, and Hopewell, J W. 1980. "Quantitative changes in the cellularity of the rat subependymal plate after X-irradiation." United Kingdom.
@misc{etde_7029035,
title = {Quantitative changes in the cellularity of the rat subependymal plate after X-irradiation}
author = {Hubbard, B, and Hopewell, J W}
abstractNote = {The brains of young adult rats were irradiated with a single dose of 8 Gy (800 rad) of 250 kVp X-rays. Within 2 weeks of treatment the cell population of the subependymal plate was reduced by 30%. During this period the cell cycle time remained unchanged but the labelling index was reduced. The cell population subsequently returned to normal after 39-52 weeks. Damage and subsequent recovery of the plate was due mainly to changes in the number of cells with small dark nuclei. Cells with small and large light nuclei were little affected. A model for the production and differentiation of cells in the subependymal region is proposed on the basis of age-related changes in the total number and proportions of the various cell types in the subependymal plate of normal rats. This is discussed both in terms of the radiation response of cells in the plate and the manifestation of delayed white matter necrosis after higher doses.}
journal = {Cell Tissue Kinet.; (United Kingdom)}
volume = {13:4}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Jul}
}