You need JavaScript to view this

Effect of /sup 60/Co-irradiation on normal and low protein diet fed rat brain

Journal Article:

Abstract

The effect of whole-body irradiation (Co-60) on the brain tissue in Holtzmann strain adult male rats was studied. Two doses of irradiation (450 R,950 R) were tried on animals which were fed on normal as well as low protein diets over a period of 10 generations. In the normal rats, 450 R initially caused a lowered total protein. DNA and RNA content in the brain. After 7 days a tendency towards normalcy was observed. In the 950 R irradiated normal rats the diminution of protein content appeared irreversible. In malnourished 450 R irradiated rats, the protein content rose less steeply over the 7 days of observation. A higher dose of 950 R enhanced this effect on protein and also lowered the DNA content on day 5. The RNA content in the 950 R group with malnutrition showed a marked increase towards or beyond control perhaps as an expression of uncoupled feedback control. The paper gives evidence that protein deficiency may interfere with cellular regeneration in irradiated brain.
Authors:
Hasan, S S; [1]  Habibullah, M [2] 
  1. Garhwal Univ., Srinagar, Uttar Pradesh (India). Dept. of Zoology
  2. Jawaharlal Nehru Univ., New Delhi (India). Neurobiology Lab.
Publication Date:
Jun 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-11-565234; EDB-81-012937
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 156:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BRAIN; PROTEINS; GAMMA RADIATION; BIOLOGICAL RADIATION EFFECTS; COBALT 60; DIET; DNA; DOSE-RESPONSE RELATIONSHIPS; QUANTITY RATIO; RATS; RESPONSE MODIFYING FACTORS; RNA; WHOLE-BODY IRRADIATION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; COBALT ISOTOPES; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7029026
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
INIS
Size:
Pages: 441-445
Announcement Date:

Journal Article:

Citation Formats

Hasan, S S, and Habibullah, M. Effect of /sup 60/Co-irradiation on normal and low protein diet fed rat brain. Germany: N. p., 1980. Web.
Hasan, S S, & Habibullah, M. Effect of /sup 60/Co-irradiation on normal and low protein diet fed rat brain. Germany.
Hasan, S S, and Habibullah, M. 1980. "Effect of /sup 60/Co-irradiation on normal and low protein diet fed rat brain." Germany.
@misc{etde_7029026,
title = {Effect of /sup 60/Co-irradiation on normal and low protein diet fed rat brain}
author = {Hasan, S S, and Habibullah, M}
abstractNote = {The effect of whole-body irradiation (Co-60) on the brain tissue in Holtzmann strain adult male rats was studied. Two doses of irradiation (450 R,950 R) were tried on animals which were fed on normal as well as low protein diets over a period of 10 generations. In the normal rats, 450 R initially caused a lowered total protein. DNA and RNA content in the brain. After 7 days a tendency towards normalcy was observed. In the 950 R irradiated normal rats the diminution of protein content appeared irreversible. In malnourished 450 R irradiated rats, the protein content rose less steeply over the 7 days of observation. A higher dose of 950 R enhanced this effect on protein and also lowered the DNA content on day 5. The RNA content in the 950 R group with malnutrition showed a marked increase towards or beyond control perhaps as an expression of uncoupled feedback control. The paper gives evidence that protein deficiency may interfere with cellular regeneration in irradiated brain.}
journal = {Strahlentherapie; (Germany, Federal Republic of)}
volume = {156:6}
journal type = {AC}
place = {Germany}
year = {1980}
month = {Jun}
}