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A facile synthesis of sodium 3-[1-[sup 14]C]-ethyl-7-isopropyl-1-azulenesulfonate

Abstract

Sodium 3-ethyl-7-isopropyl-1-azulenesulfonate 1, a new therapeutic agent for stomatitis, pharyngitis and ophthalmia was labelled with carbon-14 in the ethyl group attached to the azulene ring for use in metabolic studies. [sup 14]C-labelled 1 with a specific activity of 1.98 GBq/mmol was prepared in four steps in 39.3% overall chemical yield from [1-[sup 14]C]acetic acid sodium salt. (Author).
Authors:
Shimada, Takeshi; Yanagisawa, Takashi; Tomiyama, Tsuyoshi; [1]  Okazaki, Mitsuo [2] 
  1. Kotobuki Pharmaceutical Co. Ltd., Nagano (Japan). Research Labs.
  2. Shinshu Univ., Nagano (Japan). Dept. of Applied Biology
Publication Date:
Jan 01, 1994
Product Type:
Journal Article
Reference Number:
AIX-25-063456; EDB-94-145671
Resource Relation:
Journal Name: Journal of Labelled Compounds and Radiopharmaceuticals; (United Kingdom); Journal Volume: 34:1
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; DIGESTIVE SYSTEM DISEASES; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; SENSE ORGANS DISEASES; CARBON 14 COMPOUNDS; CONJUNCTIVA; INFLAMMATION; LABELLING; ORAL CAVITY; ORGANIC SULFUR COMPOUNDS; PHARYNX; BODY; BODY AREAS; CARBON COMPOUNDS; DIGESTIVE SYSTEM; DISEASES; DRUGS; EYES; FACE; HEAD; LABELLED COMPOUNDS; MEMBRANES; MUCOUS MEMBRANES; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; RESPIRATORY SYSTEM; SENSE ORGANS; SYMPTOMS; SYNTHESIS; 400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
OSTI ID:
7015065
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0362-4803; CODEN: JLCRD4
Submitting Site:
GBN
Size:
Pages: 79-84
Announcement Date:

Citation Formats

Shimada, Takeshi, Yanagisawa, Takashi, Tomiyama, Tsuyoshi, and Okazaki, Mitsuo. A facile synthesis of sodium 3-[1-[sup 14]C]-ethyl-7-isopropyl-1-azulenesulfonate. United Kingdom: N. p., 1994. Web. doi:10.1002/jlcr.2580340111.
Shimada, Takeshi, Yanagisawa, Takashi, Tomiyama, Tsuyoshi, & Okazaki, Mitsuo. A facile synthesis of sodium 3-[1-[sup 14]C]-ethyl-7-isopropyl-1-azulenesulfonate. United Kingdom. doi:10.1002/jlcr.2580340111.
Shimada, Takeshi, Yanagisawa, Takashi, Tomiyama, Tsuyoshi, and Okazaki, Mitsuo. 1994. "A facile synthesis of sodium 3-[1-[sup 14]C]-ethyl-7-isopropyl-1-azulenesulfonate." United Kingdom. doi:10.1002/jlcr.2580340111. https://www.osti.gov/servlets/purl/10.1002/jlcr.2580340111.
@misc{etde_7015065,
title = {A facile synthesis of sodium 3-[1-[sup 14]C]-ethyl-7-isopropyl-1-azulenesulfonate}
author = {Shimada, Takeshi, Yanagisawa, Takashi, Tomiyama, Tsuyoshi, and Okazaki, Mitsuo}
abstractNote = {Sodium 3-ethyl-7-isopropyl-1-azulenesulfonate 1, a new therapeutic agent for stomatitis, pharyngitis and ophthalmia was labelled with carbon-14 in the ethyl group attached to the azulene ring for use in metabolic studies. [sup 14]C-labelled 1 with a specific activity of 1.98 GBq/mmol was prepared in four steps in 39.3% overall chemical yield from [1-[sup 14]C]acetic acid sodium salt. (Author).}
doi = {10.1002/jlcr.2580340111}
journal = {Journal of Labelled Compounds and Radiopharmaceuticals; (United Kingdom)}
volume = {34:1}
journal type = {AC}
place = {United Kingdom}
year = {1994}
month = {Jan}
}