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The study of the androgen receptor profile and changes of level of serum testosterone in human prostatic cancer

Journal Article:

Abstract

The androgen receptors in biopsy specimens of 22 cases of human prostatic cancer (PC) were studied by radioligand binding assay. The cytoplasmic androgen receptor (AcR) and nuclear androgen receptor (AnR) densities were 305.70 +- 461.68 and 363.04 +- 391.44 pmol/g protein respectively, both were significantly higher than those of 36 benign prostatic hypertrophy (BPH) and 9 normal prostate (NP). Among the prostatic cancers, the AnR/AcR ratios were significantly different between metastatic and primary cancers. This result suggested that there might be migration of AR from nucleus to cytosol in the process of metastasis. The serum testosterone studied by RIA method are significantly lower than that of BPH and NP. Thawmounted autoradiography demonstrated that AR were mainly located in epithelial cells of the glandular tissue of prostate.
Authors:
Zhining, Gui; Xiaoke, Hu; Hanping, Lu; Wei, Fan; Naiyun, Wu; Jinhui, Gao; [1]  Hua, Mei; Jinyun, Zeng [2] 
  1. Zhongshan University of Medical Sciences, Guangzhou, GD (China)
  2. First Affiliated Hospital of Zhongshan Univ. of Medical Sciences, Guangzhou, GD (China)
Publication Date:
Nov 01, 1993
Product Type:
Journal Article
Reference Number:
AIX-25-066771; EDB-94-147289
Resource Relation:
Journal Name: Nuclear Techniques (He Jishu); (China); Journal Volume: 16:11
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD SERUM; TESTOSTERONE; PROSTATE; CARCINOMAS; ANDROGENS; LABELLING; RADIOIMMUNODETECTION; RECEPTORS; TRITIUM; ANDROSTANES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DIAGNOSTIC TECHNIQUES; DISEASES; GLANDS; HORMONES; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; ISOTOPES; KETONES; LIGHT NUCLEI; MALE GENITALS; MEMBRANE PROTEINS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; STEROID HORMONES; STEROIDS; TRACER TECHNIQUES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
7009077
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: ISSN 0523-3219; CODEN: NUTEDL
Submitting Site:
INIS
Size:
Pages: 649-652
Announcement Date:

Journal Article:

Citation Formats

Zhining, Gui, Xiaoke, Hu, Hanping, Lu, Wei, Fan, Naiyun, Wu, Jinhui, Gao, Hua, Mei, and Jinyun, Zeng. The study of the androgen receptor profile and changes of level of serum testosterone in human prostatic cancer. China: N. p., 1993. Web.
Zhining, Gui, Xiaoke, Hu, Hanping, Lu, Wei, Fan, Naiyun, Wu, Jinhui, Gao, Hua, Mei, & Jinyun, Zeng. The study of the androgen receptor profile and changes of level of serum testosterone in human prostatic cancer. China.
Zhining, Gui, Xiaoke, Hu, Hanping, Lu, Wei, Fan, Naiyun, Wu, Jinhui, Gao, Hua, Mei, and Jinyun, Zeng. 1993. "The study of the androgen receptor profile and changes of level of serum testosterone in human prostatic cancer." China.
@misc{etde_7009077,
title = {The study of the androgen receptor profile and changes of level of serum testosterone in human prostatic cancer}
author = {Zhining, Gui, Xiaoke, Hu, Hanping, Lu, Wei, Fan, Naiyun, Wu, Jinhui, Gao, Hua, Mei, and Jinyun, Zeng}
abstractNote = {The androgen receptors in biopsy specimens of 22 cases of human prostatic cancer (PC) were studied by radioligand binding assay. The cytoplasmic androgen receptor (AcR) and nuclear androgen receptor (AnR) densities were 305.70 +- 461.68 and 363.04 +- 391.44 pmol/g protein respectively, both were significantly higher than those of 36 benign prostatic hypertrophy (BPH) and 9 normal prostate (NP). Among the prostatic cancers, the AnR/AcR ratios were significantly different between metastatic and primary cancers. This result suggested that there might be migration of AR from nucleus to cytosol in the process of metastasis. The serum testosterone studied by RIA method are significantly lower than that of BPH and NP. Thawmounted autoradiography demonstrated that AR were mainly located in epithelial cells of the glandular tissue of prostate.}
journal = {Nuclear Techniques (He Jishu); (China)}
volume = {16:11}
journal type = {AC}
place = {China}
year = {1993}
month = {Nov}
}