Abstract
We have previously developed the clinostat-microgravity rat model as a new ground-based model for clarifying the changes that occur in systemic bone and calcium metabolism in the space environment. The aims of present study were to examine the effects of a 2-week period of clinostat-microgravity, which is the average period of space flight, so that the results could be compared with those of previous reports; exposure to heavy-particle radiation, a component of cosmic rays; and the combination of clinostat-microgravity and radiation on bone and calcium metabolism in rats. Bone mineral density, histomorphometric values, the breaking force of bone, intestinal calcium absorption, urinary calcium excretion, calcium regulating hormones (PTH and BGP), and weights of adrenal gland and skeletal muscles were measured. The clinostat-microgravity model produced a low bone turnover with decreases in bone formation and resorption, trabecular BMD, intestinal calcium absorption, and BGP concentration, and increase in PTH concentration, but other data remained unchanged or actually increased. Exposure to heavy-particle radiation inhibited bone metabolism, e.g. lack of bone labels, with doses of 1.25-5.0 Gy as well as changes in the bones, intestinal calcium absorption, urinary calcium excretion, PTH and BGP concentrations. With a combination of both clinostat-microgravity and radiation, such changes
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Citation Formats
Fukuda, Satoshi, and Iida, Haruzo.
Effects of clinostat microgravity and heavy-particle radiation on bone and calcium metabolism in rats.
Japan: N. p.,
1999.
Web.
Fukuda, Satoshi, & Iida, Haruzo.
Effects of clinostat microgravity and heavy-particle radiation on bone and calcium metabolism in rats.
Japan.
Fukuda, Satoshi, and Iida, Haruzo.
1999.
"Effects of clinostat microgravity and heavy-particle radiation on bone and calcium metabolism in rats."
Japan.
@misc{etde_700771,
title = {Effects of clinostat microgravity and heavy-particle radiation on bone and calcium metabolism in rats}
author = {Fukuda, Satoshi, and Iida, Haruzo}
abstractNote = {We have previously developed the clinostat-microgravity rat model as a new ground-based model for clarifying the changes that occur in systemic bone and calcium metabolism in the space environment. The aims of present study were to examine the effects of a 2-week period of clinostat-microgravity, which is the average period of space flight, so that the results could be compared with those of previous reports; exposure to heavy-particle radiation, a component of cosmic rays; and the combination of clinostat-microgravity and radiation on bone and calcium metabolism in rats. Bone mineral density, histomorphometric values, the breaking force of bone, intestinal calcium absorption, urinary calcium excretion, calcium regulating hormones (PTH and BGP), and weights of adrenal gland and skeletal muscles were measured. The clinostat-microgravity model produced a low bone turnover with decreases in bone formation and resorption, trabecular BMD, intestinal calcium absorption, and BGP concentration, and increase in PTH concentration, but other data remained unchanged or actually increased. Exposure to heavy-particle radiation inhibited bone metabolism, e.g. lack of bone labels, with doses of 1.25-5.0 Gy as well as changes in the bones, intestinal calcium absorption, urinary calcium excretion, PTH and BGP concentrations. With a combination of both clinostat-microgravity and radiation, such changes tended to be more pronounced, and noticeable findings were to find out the bone labels in the groups irradiated 1.25 and 2.5 Gy, but no bone label was observed in the group irradiated 5.0 Gy. Based on the gathered data, the utility of the clinostat-mirogravity model, the effects of the short-term experiment, the exposure to radiation, and the combination of clinostat-microgravity and radiation are discussed. (author)}
journal = []
issue = {1}
volume = {9}
journal type = {AC}
place = {Japan}
year = {1999}
month = {May}
}
title = {Effects of clinostat microgravity and heavy-particle radiation on bone and calcium metabolism in rats}
author = {Fukuda, Satoshi, and Iida, Haruzo}
abstractNote = {We have previously developed the clinostat-microgravity rat model as a new ground-based model for clarifying the changes that occur in systemic bone and calcium metabolism in the space environment. The aims of present study were to examine the effects of a 2-week period of clinostat-microgravity, which is the average period of space flight, so that the results could be compared with those of previous reports; exposure to heavy-particle radiation, a component of cosmic rays; and the combination of clinostat-microgravity and radiation on bone and calcium metabolism in rats. Bone mineral density, histomorphometric values, the breaking force of bone, intestinal calcium absorption, urinary calcium excretion, calcium regulating hormones (PTH and BGP), and weights of adrenal gland and skeletal muscles were measured. The clinostat-microgravity model produced a low bone turnover with decreases in bone formation and resorption, trabecular BMD, intestinal calcium absorption, and BGP concentration, and increase in PTH concentration, but other data remained unchanged or actually increased. Exposure to heavy-particle radiation inhibited bone metabolism, e.g. lack of bone labels, with doses of 1.25-5.0 Gy as well as changes in the bones, intestinal calcium absorption, urinary calcium excretion, PTH and BGP concentrations. With a combination of both clinostat-microgravity and radiation, such changes tended to be more pronounced, and noticeable findings were to find out the bone labels in the groups irradiated 1.25 and 2.5 Gy, but no bone label was observed in the group irradiated 5.0 Gy. Based on the gathered data, the utility of the clinostat-mirogravity model, the effects of the short-term experiment, the exposure to radiation, and the combination of clinostat-microgravity and radiation are discussed. (author)}
journal = []
issue = {1}
volume = {9}
journal type = {AC}
place = {Japan}
year = {1999}
month = {May}
}