Abstract
The effects of pharmacological intervention on brain muscarinic cholinergic receptor (mAChR) binding were assessed in seven patients with Parkinson's disease by positron emission tomography and carbon-11 labelled N-methyl-4-piperidyl benzilate ([[sup 11]C]NMPB). [[sup 11]C]NMPB was injected twice, approximately 2 hours apart, in each patient, to assess the effect of single doses of 4 mg of trihexyphenidyl (n=5) or 400 mg of L-dopa with 57 mg of benserazide (n=2) on the binding parameter of mAChRs (K[sub 3]). There was a mean 28% inhibition of K[sub 3] values in the brain in the presence of trihexyphenidyl, which was assumed to reflect mAChR occupancy. No significant change in K[sub 3] was observed in the presence of L-dopa. This study demonstrates the feasibility of measuring mAChR occupancy by an anticholinergic medication with PET.
Shinotoh, H;
Asahina, M;
Hirayama, K;
[1]
Inoue, O;
Suhara, T;
Tateno, Y
[2]
- Dept. of Neurology, School of Medicine, Chiba Univ., Chiba (Japan)
- Division of Clinical Research, National Inst. of Radiological Sciences, Chiba (Japan)
Citation Formats
Shinotoh, H, Asahina, M, Hirayama, K, Inoue, O, Suhara, T, and Tateno, Y.
Effects of trihexyphenidyl and L-dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography.
Austria: N. p.,
1994.
Web.
doi:10.1007/BF02252661.
Shinotoh, H, Asahina, M, Hirayama, K, Inoue, O, Suhara, T, & Tateno, Y.
Effects of trihexyphenidyl and L-dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography.
Austria.
https://doi.org/10.1007/BF02252661
Shinotoh, H, Asahina, M, Hirayama, K, Inoue, O, Suhara, T, and Tateno, Y.
1994.
"Effects of trihexyphenidyl and L-dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography."
Austria.
https://doi.org/10.1007/BF02252661.
@misc{etde_7000837,
title = {Effects of trihexyphenidyl and L-dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography}
author = {Shinotoh, H, Asahina, M, Hirayama, K, Inoue, O, Suhara, T, and Tateno, Y}
abstractNote = {The effects of pharmacological intervention on brain muscarinic cholinergic receptor (mAChR) binding were assessed in seven patients with Parkinson's disease by positron emission tomography and carbon-11 labelled N-methyl-4-piperidyl benzilate ([[sup 11]C]NMPB). [[sup 11]C]NMPB was injected twice, approximately 2 hours apart, in each patient, to assess the effect of single doses of 4 mg of trihexyphenidyl (n=5) or 400 mg of L-dopa with 57 mg of benserazide (n=2) on the binding parameter of mAChRs (K[sub 3]). There was a mean 28% inhibition of K[sub 3] values in the brain in the presence of trihexyphenidyl, which was assumed to reflect mAChR occupancy. No significant change in K[sub 3] was observed in the presence of L-dopa. This study demonstrates the feasibility of measuring mAChR occupancy by an anticholinergic medication with PET.}
doi = {10.1007/BF02252661}
journal = []
volume = {7}
journal type = {AC}
place = {Austria}
year = {1994}
month = {Jan}
}
title = {Effects of trihexyphenidyl and L-dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography}
author = {Shinotoh, H, Asahina, M, Hirayama, K, Inoue, O, Suhara, T, and Tateno, Y}
abstractNote = {The effects of pharmacological intervention on brain muscarinic cholinergic receptor (mAChR) binding were assessed in seven patients with Parkinson's disease by positron emission tomography and carbon-11 labelled N-methyl-4-piperidyl benzilate ([[sup 11]C]NMPB). [[sup 11]C]NMPB was injected twice, approximately 2 hours apart, in each patient, to assess the effect of single doses of 4 mg of trihexyphenidyl (n=5) or 400 mg of L-dopa with 57 mg of benserazide (n=2) on the binding parameter of mAChRs (K[sub 3]). There was a mean 28% inhibition of K[sub 3] values in the brain in the presence of trihexyphenidyl, which was assumed to reflect mAChR occupancy. No significant change in K[sub 3] was observed in the presence of L-dopa. This study demonstrates the feasibility of measuring mAChR occupancy by an anticholinergic medication with PET.}
doi = {10.1007/BF02252661}
journal = []
volume = {7}
journal type = {AC}
place = {Austria}
year = {1994}
month = {Jan}
}