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5' Region of the human interleukin 4 gene: structure and potential regulatory elements

Journal Article:

Abstract

The lymphokine Interleukin 4 (IL-4) is secreted by antigen or mitogen activated T lymphocytes. IL-4 stimulates activation and differentiation of B lymphocytes and growth of T lymphocytes and mast cells. The authors isolated the human IL-4 gene from a lambda EMBL3 genomic library. As a probe they used a synthetic oligonucleotide spanning position 40 to 79 of the published IL-4 cDNA sequence. The 5' promoter region contains several sequence elements which may have a cis-acting regulatory function for IL-4 gene expression. These elements include a TATA-box, three CCAAT-elements (two are on the non-coding strand) and an octamer motif. A comparison of the 5' flanking region of the human murine IL-4 gene (4) shows that the region between position -306 and +44 is highly conserved (83% homology).
Publication Date:
Jan 25, 1988
Product Type:
Journal Article
Reference Number:
EDB-88-143550
Resource Relation:
Journal Name: Nucleic Acids Res.; (United Kingdom); Journal Volume: 16:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; LYMPHOKINES; DNA SEQUENCING; GENE REGULATION; MAN; MICE; OLIGONUCLEOTIDES; PHOSPHORUS 32; RECOMBINANT DNA; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DNA; GROWTH FACTORS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MITOGENS; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PHOSPHORUS ISOTOPES; PRIMATES; PROTEINS; RADIOISOTOPES; RODENTS; STRUCTURAL CHEMICAL ANALYSIS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques
OSTI ID:
6998170
Research Organizations:
German Cancer Research Center, Heidelberg (West Germany)
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NARHA
Submitting Site:
JMT
Size:
Pages: 772
Announcement Date:

Journal Article:

Citation Formats

Eder, A, Krafft-Czepa, H, and Krammer, P H. 5' Region of the human interleukin 4 gene: structure and potential regulatory elements. United Kingdom: N. p., 1988. Web. doi:10.1093/nar/16.2.772.
Eder, A, Krafft-Czepa, H, & Krammer, P H. 5' Region of the human interleukin 4 gene: structure and potential regulatory elements. United Kingdom. doi:10.1093/nar/16.2.772.
Eder, A, Krafft-Czepa, H, and Krammer, P H. 1988. "5' Region of the human interleukin 4 gene: structure and potential regulatory elements." United Kingdom. doi:10.1093/nar/16.2.772. https://www.osti.gov/servlets/purl/10.1093/nar/16.2.772.
@misc{etde_6998170,
title = {5' Region of the human interleukin 4 gene: structure and potential regulatory elements}
author = {Eder, A, Krafft-Czepa, H, and Krammer, P H}
abstractNote = {The lymphokine Interleukin 4 (IL-4) is secreted by antigen or mitogen activated T lymphocytes. IL-4 stimulates activation and differentiation of B lymphocytes and growth of T lymphocytes and mast cells. The authors isolated the human IL-4 gene from a lambda EMBL3 genomic library. As a probe they used a synthetic oligonucleotide spanning position 40 to 79 of the published IL-4 cDNA sequence. The 5' promoter region contains several sequence elements which may have a cis-acting regulatory function for IL-4 gene expression. These elements include a TATA-box, three CCAAT-elements (two are on the non-coding strand) and an octamer motif. A comparison of the 5' flanking region of the human murine IL-4 gene (4) shows that the region between position -306 and +44 is highly conserved (83% homology).}
doi = {10.1093/nar/16.2.772}
journal = {Nucleic Acids Res.; (United Kingdom)}
volume = {16:2}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Jan}
}