Abstract
The lymphokine Interleukin 4 (IL-4) is secreted by antigen or mitogen activated T lymphocytes. IL-4 stimulates activation and differentiation of B lymphocytes and growth of T lymphocytes and mast cells. The authors isolated the human IL-4 gene from a lambda EMBL3 genomic library. As a probe they used a synthetic oligonucleotide spanning position 40 to 79 of the published IL-4 cDNA sequence. The 5' promoter region contains several sequence elements which may have a cis-acting regulatory function for IL-4 gene expression. These elements include a TATA-box, three CCAAT-elements (two are on the non-coding strand) and an octamer motif. A comparison of the 5' flanking region of the human murine IL-4 gene (4) shows that the region between position -306 and +44 is highly conserved (83% homology).
Citation Formats
Eder, A, Krafft-Czepa, H, and Krammer, P H.
5' Region of the human interleukin 4 gene: structure and potential regulatory elements.
United Kingdom: N. p.,
1988.
Web.
doi:10.1093/nar/16.2.772.
Eder, A, Krafft-Czepa, H, & Krammer, P H.
5' Region of the human interleukin 4 gene: structure and potential regulatory elements.
United Kingdom.
https://doi.org/10.1093/nar/16.2.772
Eder, A, Krafft-Czepa, H, and Krammer, P H.
1988.
"5' Region of the human interleukin 4 gene: structure and potential regulatory elements."
United Kingdom.
https://doi.org/10.1093/nar/16.2.772.
@misc{etde_6998170,
title = {5' Region of the human interleukin 4 gene: structure and potential regulatory elements}
author = {Eder, A, Krafft-Czepa, H, and Krammer, P H}
abstractNote = {The lymphokine Interleukin 4 (IL-4) is secreted by antigen or mitogen activated T lymphocytes. IL-4 stimulates activation and differentiation of B lymphocytes and growth of T lymphocytes and mast cells. The authors isolated the human IL-4 gene from a lambda EMBL3 genomic library. As a probe they used a synthetic oligonucleotide spanning position 40 to 79 of the published IL-4 cDNA sequence. The 5' promoter region contains several sequence elements which may have a cis-acting regulatory function for IL-4 gene expression. These elements include a TATA-box, three CCAAT-elements (two are on the non-coding strand) and an octamer motif. A comparison of the 5' flanking region of the human murine IL-4 gene (4) shows that the region between position -306 and +44 is highly conserved (83% homology).}
doi = {10.1093/nar/16.2.772}
journal = []
volume = {16:2}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Jan}
}
title = {5' Region of the human interleukin 4 gene: structure and potential regulatory elements}
author = {Eder, A, Krafft-Czepa, H, and Krammer, P H}
abstractNote = {The lymphokine Interleukin 4 (IL-4) is secreted by antigen or mitogen activated T lymphocytes. IL-4 stimulates activation and differentiation of B lymphocytes and growth of T lymphocytes and mast cells. The authors isolated the human IL-4 gene from a lambda EMBL3 genomic library. As a probe they used a synthetic oligonucleotide spanning position 40 to 79 of the published IL-4 cDNA sequence. The 5' promoter region contains several sequence elements which may have a cis-acting regulatory function for IL-4 gene expression. These elements include a TATA-box, three CCAAT-elements (two are on the non-coding strand) and an octamer motif. A comparison of the 5' flanking region of the human murine IL-4 gene (4) shows that the region between position -306 and +44 is highly conserved (83% homology).}
doi = {10.1093/nar/16.2.772}
journal = []
volume = {16:2}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Jan}
}