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Regional cerebral blood flow in Parkinson's disease measured with N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT

Journal Article:

Abstract

N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT studies were performed on 21 patients (13 females; 45-73 yrs) with idiopathic Parkinson's disease (PD) and 10 age-matched normal controls (39-69 yrs). Regional cerebral blood flow (rCBF) was quantitatively measured by the arterial blood sampling method. When compared with normal controls, global CBF, and rCBF in the frontal cortex and in the basal ganglia were reduced 22.1% (p<0.01), 25.0% (p<0.05) and 25.6% (p<0.01), respectively. The reduction of rCBF in the basal ganglia was significantly correlated (p<0.05) with symptoms such as gait disturbance, frozen gait and motor disability score. However, no significant correlation was observed between the severity of dementia and any regional reduction of CBF, including the frontal or parietal cortices. These data show that the severity of dementia in PD may be related to other factors but not with CBF. Quantification of rCBF with [sup 123]I-IMP SPECT imaging is useful for evaluation and follow-up of patients with PD. (author).
Authors:
Odano, Ikuo; Nishihara, Mamiko; Hayashi, Hiroko; Higuchi, Shoichi; Sakai, Kunio; [1]  Ishikawa, Atsushi; Ibayashi, Katsuhiko
  1. Niigata Univ. (Japan). School of Medicine
Publication Date:
Sep 01, 1992
Product Type:
Journal Article
Reference Number:
JPN-93-001191; EDB-93-025242
Resource Relation:
Journal Name: Acta Medica et Biologica (Niigata); (Japan); Journal Volume: 40:3
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRAL CORTEX; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; IODINE 123; ATROPHY; BENZEDRINE; BLOOD FLOW; MENTAL DISORDERS; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; CEREBRUM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6997912
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0567-7734; CODEN: AMBNAS
Submitting Site:
JPN
Size:
Pages: 115-121
Announcement Date:
Mar 01, 1993

Journal Article:

Citation Formats

Odano, Ikuo, Nishihara, Mamiko, Hayashi, Hiroko, Higuchi, Shoichi, Sakai, Kunio, Ishikawa, Atsushi, and Ibayashi, Katsuhiko. Regional cerebral blood flow in Parkinson's disease measured with N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT. Japan: N. p., 1992. Web.
Odano, Ikuo, Nishihara, Mamiko, Hayashi, Hiroko, Higuchi, Shoichi, Sakai, Kunio, Ishikawa, Atsushi, & Ibayashi, Katsuhiko. Regional cerebral blood flow in Parkinson's disease measured with N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT. Japan.
Odano, Ikuo, Nishihara, Mamiko, Hayashi, Hiroko, Higuchi, Shoichi, Sakai, Kunio, Ishikawa, Atsushi, and Ibayashi, Katsuhiko. 1992. "Regional cerebral blood flow in Parkinson's disease measured with N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT." Japan.
@misc{etde_6997912,
title = {Regional cerebral blood flow in Parkinson's disease measured with N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT}
author = {Odano, Ikuo, Nishihara, Mamiko, Hayashi, Hiroko, Higuchi, Shoichi, Sakai, Kunio, Ishikawa, Atsushi, and Ibayashi, Katsuhiko}
abstractNote = {N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT studies were performed on 21 patients (13 females; 45-73 yrs) with idiopathic Parkinson's disease (PD) and 10 age-matched normal controls (39-69 yrs). Regional cerebral blood flow (rCBF) was quantitatively measured by the arterial blood sampling method. When compared with normal controls, global CBF, and rCBF in the frontal cortex and in the basal ganglia were reduced 22.1% (p<0.01), 25.0% (p<0.05) and 25.6% (p<0.01), respectively. The reduction of rCBF in the basal ganglia was significantly correlated (p<0.05) with symptoms such as gait disturbance, frozen gait and motor disability score. However, no significant correlation was observed between the severity of dementia and any regional reduction of CBF, including the frontal or parietal cortices. These data show that the severity of dementia in PD may be related to other factors but not with CBF. Quantification of rCBF with [sup 123]I-IMP SPECT imaging is useful for evaluation and follow-up of patients with PD. (author).}
journal = {Acta Medica et Biologica (Niigata); (Japan)}
volume = {40:3}
journal type = {AC}
place = {Japan}
year = {1992}
month = {Sep}
}