Abstract
Bacterial endotoxins (lipopolysaccharides) were found to suppress X-ray-induced malignant transformation of C3H/10T1/2 cells. Endotoxins were effective if present either throughout the 6-week transformation assay period, or for the final 4-week phase, but not when present only for the initial 2-week phase. Neither growth nor survival of C3H/10T1/2 cells, or a radiation-transformed cell line derived from them, were affected by endotoxins. Also, the endotoxins did not affect the formation of foci by the radiation transformed cells when these cells were co-cultured with untransformed cells. These results suggest that endotoxins exert their effect directly upon the transformation process itself, perhaps at a 'late' step in the conversion of an untransformed to a transformed cell.
Citation Formats
Carew, J A, Collins, M F, and Kennedy, A R.
Inhibition of radiation-induced transformation in vitro by bacterial endotoxins.
United Kingdom: N. p.,
1988.
Web.
doi:10.1093/carcin/9.5.725.
Carew, J A, Collins, M F, & Kennedy, A R.
Inhibition of radiation-induced transformation in vitro by bacterial endotoxins.
United Kingdom.
https://doi.org/10.1093/carcin/9.5.725
Carew, J A, Collins, M F, and Kennedy, A R.
1988.
"Inhibition of radiation-induced transformation in vitro by bacterial endotoxins."
United Kingdom.
https://doi.org/10.1093/carcin/9.5.725.
@misc{etde_6969145,
title = {Inhibition of radiation-induced transformation in vitro by bacterial endotoxins}
author = {Carew, J A, Collins, M F, and Kennedy, A R}
abstractNote = {Bacterial endotoxins (lipopolysaccharides) were found to suppress X-ray-induced malignant transformation of C3H/10T1/2 cells. Endotoxins were effective if present either throughout the 6-week transformation assay period, or for the final 4-week phase, but not when present only for the initial 2-week phase. Neither growth nor survival of C3H/10T1/2 cells, or a radiation-transformed cell line derived from them, were affected by endotoxins. Also, the endotoxins did not affect the formation of foci by the radiation transformed cells when these cells were co-cultured with untransformed cells. These results suggest that endotoxins exert their effect directly upon the transformation process itself, perhaps at a 'late' step in the conversion of an untransformed to a transformed cell.}
doi = {10.1093/carcin/9.5.725}
journal = []
volume = {9:5}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {May}
}
title = {Inhibition of radiation-induced transformation in vitro by bacterial endotoxins}
author = {Carew, J A, Collins, M F, and Kennedy, A R}
abstractNote = {Bacterial endotoxins (lipopolysaccharides) were found to suppress X-ray-induced malignant transformation of C3H/10T1/2 cells. Endotoxins were effective if present either throughout the 6-week transformation assay period, or for the final 4-week phase, but not when present only for the initial 2-week phase. Neither growth nor survival of C3H/10T1/2 cells, or a radiation-transformed cell line derived from them, were affected by endotoxins. Also, the endotoxins did not affect the formation of foci by the radiation transformed cells when these cells were co-cultured with untransformed cells. These results suggest that endotoxins exert their effect directly upon the transformation process itself, perhaps at a 'late' step in the conversion of an untransformed to a transformed cell.}
doi = {10.1093/carcin/9.5.725}
journal = []
volume = {9:5}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {May}
}