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Experimental studies on Diethon, a new radioprotective substance of the skin. Ein neuer Haut-Radioprotektor Diethon (experimentelle Untersuchung)

Journal Article:

Abstract

Results are represented on investigations of diethone, a new pharmacon to prevent and treat radiogenic skin injuries. Diethone is a synthetic antioxidant of the dihydropyridine line. In animal experiments the preparation was used in form of an oitment. Irradiation was done with beta and soft roentgen rays in doses of 20 to 60 Gy on conditions of a tele or contact radiotherapy. A reduction of intensity and duration of radioreactions by more than 50% and a slighter occurrence of radioreactions were shown. The protecting effect of diethone is much stronger than that of mexamine, cystamine and other radioprotectors. Application of this preparation in treatment of radiogenic dermatitides results in relief of inflammation appearances, in shortening of recovery time, and in accelerated skin regeneration. The intravital investigations of skin by means of contact luminescence microscopy and investigations using light and electron microscopy did not give any alterations in structure of regenerated skin in diethone-treated animals compared with controls. Also a better conservation of protected intracellular membranes especially of mitochondrial membranes were seen. General penetration of {sup 14}C-diethone into skin occurs within two hours after application of oitment. (author).
Authors:
Ivanov, E V; Ponomarjova, T V; Merkusev, G N; Dubur, G Ya; Bisenieks, E A; Dauvorte, A Z; Pilscik, E M [1] 
  1. Nauchno-Issledovatel'skij Inst. Radiatsionnoj Gigieny, Leningrad (USSR) AN Latvijskoj SSR, Riga (USSR). Inst. Organicheskogo Sinteza
Publication Date:
Jan 01, 1990
Product Type:
Journal Article
Reference Number:
AIX-21-042835; EDB-90-081424
Resource Relation:
Journal Name: Radiobiologia Radiotherapia (Internationale Zeitschrift fuer das Gebiet der Strahlentherapie, Strahlenbiologie, Strahlenphysik and Nuklearmedizin); (German Democratic Republic); Journal Volume: 31:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIODERMATITIS; RADIOPROTECTIVE SUBSTANCES; SKIN; LOCAL IRRADIATION; COMPARATIVE EVALUATIONS; EXPERIMENTAL DATA; MEXAMINE; RATS; THALLIUM 204; X RADIATION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DATA; DERMATITIS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; ETHERS; HEAVY NUCLEI; INFORMATION; INJURIES; IONIZING RADIATIONS; IRRADIATION; ISOTOPES; LOCAL RADIATION EFFECTS; MAMMALS; NUCLEI; NUMERICAL DATA; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATION INJURIES; RADIATIONS; RADIOISOTOPES; RODENTS; SKIN DISEASES; THALLIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6956963
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: ISSN 0033-8184; CODEN: RDBGA
Submitting Site:
INIS
Size:
Pages: 69-78
Announcement Date:
Jun 01, 1990

Journal Article:

Citation Formats

Ivanov, E V, Ponomarjova, T V, Merkusev, G N, Dubur, G Ya, Bisenieks, E A, Dauvorte, A Z, and Pilscik, E M. Experimental studies on Diethon, a new radioprotective substance of the skin. Ein neuer Haut-Radioprotektor Diethon (experimentelle Untersuchung). Germany: N. p., 1990. Web.
Ivanov, E V, Ponomarjova, T V, Merkusev, G N, Dubur, G Ya, Bisenieks, E A, Dauvorte, A Z, & Pilscik, E M. Experimental studies on Diethon, a new radioprotective substance of the skin. Ein neuer Haut-Radioprotektor Diethon (experimentelle Untersuchung). Germany.
Ivanov, E V, Ponomarjova, T V, Merkusev, G N, Dubur, G Ya, Bisenieks, E A, Dauvorte, A Z, and Pilscik, E M. 1990. "Experimental studies on Diethon, a new radioprotective substance of the skin. Ein neuer Haut-Radioprotektor Diethon (experimentelle Untersuchung)." Germany.
@misc{etde_6956963,
title = {Experimental studies on Diethon, a new radioprotective substance of the skin. Ein neuer Haut-Radioprotektor Diethon (experimentelle Untersuchung)}
author = {Ivanov, E V, Ponomarjova, T V, Merkusev, G N, Dubur, G Ya, Bisenieks, E A, Dauvorte, A Z, and Pilscik, E M}
abstractNote = {Results are represented on investigations of diethone, a new pharmacon to prevent and treat radiogenic skin injuries. Diethone is a synthetic antioxidant of the dihydropyridine line. In animal experiments the preparation was used in form of an oitment. Irradiation was done with beta and soft roentgen rays in doses of 20 to 60 Gy on conditions of a tele or contact radiotherapy. A reduction of intensity and duration of radioreactions by more than 50% and a slighter occurrence of radioreactions were shown. The protecting effect of diethone is much stronger than that of mexamine, cystamine and other radioprotectors. Application of this preparation in treatment of radiogenic dermatitides results in relief of inflammation appearances, in shortening of recovery time, and in accelerated skin regeneration. The intravital investigations of skin by means of contact luminescence microscopy and investigations using light and electron microscopy did not give any alterations in structure of regenerated skin in diethone-treated animals compared with controls. Also a better conservation of protected intracellular membranes especially of mitochondrial membranes were seen. General penetration of {sup 14}C-diethone into skin occurs within two hours after application of oitment. (author).}
journal = {Radiobiologia Radiotherapia (Internationale Zeitschrift fuer das Gebiet der Strahlentherapie, Strahlenbiologie, Strahlenphysik and Nuklearmedizin); (German Democratic Republic)}
volume = {31:1}
journal type = {AC}
place = {Germany}
year = {1990}
month = {Jan}
}