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Results from a new mathematical model of gastrointestinal transit that incorporates age and gender-dependent physiological parameters

Abstract

Recently published data on effects of age and gender-dependent GI physiology and motility have been used to develop a new mathematical model describing the transit and adsorption of substances through the GI tract. This mathematical description of GI tract kinetics utilises more physiologically accurate transit processes than the ICRP Report 30 GI model. The model uses a combination of zero and first-order kinetics to describe motility. Some of the physiological parameters that the new model uses are gender, age, phase of the menstrual cycle, meal composition and gastric phase (solid versus liquid). A computer algorithm based on this model has been derived and results for young males are compared to those of the ICRP 30 model. Comparison of gastrointestinal residence times for {sup 99}Tc{sup m} and {sup 111}In labelled compounds, as a function of gender and age, are also presented. (author).
Authors:
Stubbs, J B [1] 
  1. Oak Ridge Associated Universities, Inc., TN (United States). Medical and Health Science Div.
Publication Date:
Jan 01, 1992
Product Type:
Conference
Report Number:
CONF-911128-
Reference Number:
AIX-23-086335; EDB-92-181544
Resource Relation:
Journal Name: Radiation Protection Dosimetry; (United Kingdom); Journal Volume: 41:2-4; Conference: Age dependent factors in biokinetics and dosimetry of radionuclides, Schloss Elmau (Germany), 5-8 Nov 1991
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GASTROINTESTINAL TRACT; RADIATION DOSES; AGE DEPENDENCE; SEX DEPENDENCE; ALGORITHMS; INDIUM 111; MATHEMATICAL MODELS; MENSTRUAL CYCLE; RADIONUCLIDE KINETICS; TECHNETIUM 99; TIME DEPENDENCE; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DOSES; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATHEMATICAL LOGIC; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; TECHNETIUM ISOTOPES; YEARS LIVING RADIOI; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man
OSTI ID:
6952729
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0144-8420; CODEN: RPDOD; Other: CNN: DE-AC05-76OR00033
Submitting Site:
GBN
Size:
Pages: 63-69
Announcement Date:
May 13, 2001

Citation Formats

Stubbs, J B. Results from a new mathematical model of gastrointestinal transit that incorporates age and gender-dependent physiological parameters. United Kingdom: N. p., 1992. Web.
Stubbs, J B. Results from a new mathematical model of gastrointestinal transit that incorporates age and gender-dependent physiological parameters. United Kingdom.
Stubbs, J B. 1992. "Results from a new mathematical model of gastrointestinal transit that incorporates age and gender-dependent physiological parameters." United Kingdom.
@misc{etde_6952729,
title = {Results from a new mathematical model of gastrointestinal transit that incorporates age and gender-dependent physiological parameters}
author = {Stubbs, J B}
abstractNote = {Recently published data on effects of age and gender-dependent GI physiology and motility have been used to develop a new mathematical model describing the transit and adsorption of substances through the GI tract. This mathematical description of GI tract kinetics utilises more physiologically accurate transit processes than the ICRP Report 30 GI model. The model uses a combination of zero and first-order kinetics to describe motility. Some of the physiological parameters that the new model uses are gender, age, phase of the menstrual cycle, meal composition and gastric phase (solid versus liquid). A computer algorithm based on this model has been derived and results for young males are compared to those of the ICRP 30 model. Comparison of gastrointestinal residence times for {sup 99}Tc{sup m} and {sup 111}In labelled compounds, as a function of gender and age, are also presented. (author).}
journal = []
volume = {41:2-4}
place = {United Kingdom}
year = {1992}
month = {Jan}
}