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Three-dimensional surface display of brain perfusion with [sup 123]I-IMP in Parkinson's disease

Abstract

We reconstructed three-dimensional (3D) surface images from single-photon emission computed tomography (SPECT) data using N-isopropyl-p[[sup 123]I]-iodoamphetamine ([sup 123]I-IMP) in 27 patients with Parkinson's disease and 11 normal control subjects. The 3D reconstruction was performed using distance-shaded methods at threshold levels with an interval of 5% from 45-80%. Any area of decreased perfusion at each threshold level was visualised as a defect area by the algorithm. In nondemented patients with Parkinson's disease, perfusion defects were frequently found in the parietal cortex at a threshold value of 65%. In demented patients, perfusion defects were frequently seen at thresholds of 45-65%, and were more marked in the temporal and parietal cortex bilaterally. This suggests that dementia in Parkinson's disease is related to a reduction of perfusion in the temporoparietal cortex. (orig.)
Authors:
Tachibana, H; [1]  Kawabata, K; [1]  Tomino, Y; [1]  Sugita, M; [1]  Fukuchi, M [2] 
  1. Fifth Dept. of Internal Medicine, Hyogo Coll. of Medicine, Nishinomiya (Japan)
  2. Dept. of Nuclear Medicine, Hyogo Coll. of Medicine, Nishinomiya (Japan)
Publication Date:
May 01, 1994
Product Type:
Journal Article
Reference Number:
DEN-94-0FP063; EDB-95-024937
Resource Relation:
Journal Name: Neuroradiology; (Germany); Journal Volume: 36:4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; PATHOLOGICAL CHANGES; PATIENTS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; BLOOD FLOW; IODINE 123; IODINE COMPOUNDS; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HALOGEN COMPOUNDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6940301
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0028-3940; CODEN: NRDYAB
Submitting Site:
DEN
Size:
Pages: 276-280
Announcement Date:
Feb 15, 1995

Citation Formats

Tachibana, H, Kawabata, K, Tomino, Y, Sugita, M, and Fukuchi, M. Three-dimensional surface display of brain perfusion with [sup 123]I-IMP in Parkinson's disease. Germany: N. p., 1994. Web. doi:10.1007/BF00593259.
Tachibana, H, Kawabata, K, Tomino, Y, Sugita, M, & Fukuchi, M. Three-dimensional surface display of brain perfusion with [sup 123]I-IMP in Parkinson's disease. Germany. https://doi.org/10.1007/BF00593259
Tachibana, H, Kawabata, K, Tomino, Y, Sugita, M, and Fukuchi, M. 1994. "Three-dimensional surface display of brain perfusion with [sup 123]I-IMP in Parkinson's disease." Germany. https://doi.org/10.1007/BF00593259.
@misc{etde_6940301,
title = {Three-dimensional surface display of brain perfusion with [sup 123]I-IMP in Parkinson's disease}
author = {Tachibana, H, Kawabata, K, Tomino, Y, Sugita, M, and Fukuchi, M}
abstractNote = {We reconstructed three-dimensional (3D) surface images from single-photon emission computed tomography (SPECT) data using N-isopropyl-p[[sup 123]I]-iodoamphetamine ([sup 123]I-IMP) in 27 patients with Parkinson's disease and 11 normal control subjects. The 3D reconstruction was performed using distance-shaded methods at threshold levels with an interval of 5% from 45-80%. Any area of decreased perfusion at each threshold level was visualised as a defect area by the algorithm. In nondemented patients with Parkinson's disease, perfusion defects were frequently found in the parietal cortex at a threshold value of 65%. In demented patients, perfusion defects were frequently seen at thresholds of 45-65%, and were more marked in the temporal and parietal cortex bilaterally. This suggests that dementia in Parkinson's disease is related to a reduction of perfusion in the temporoparietal cortex. (orig.)}
doi = {10.1007/BF00593259}
journal = []
volume = {36:4}
journal type = {AC}
place = {Germany}
year = {1994}
month = {May}
}