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Development of a model system to study leukotriene-induced modification of radiation sensitivity in mammalian cells

Abstract

Leukotrienes (LT) are an important class of biological mediators for which no information exists concerning their synthesis following a radiation insult or on their ability to modify cellular response to a subsequent radiation exposure. Results are presented which illustrate that the Chinese hamster lung fibroblast cell line, V79A03, is useful as a model system to study the metabolic fate of leukotrienes and the effect of LT on radiation sensitivity of mammalian cells in vitro. (U.K.).
Publication Date:
Jan 01, 1986
Product Type:
Journal Article
Reference Number:
GBN-88-002865; EDB-88-134618
Resource Relation:
Journal Name: Progr. Lipid Res.; (United Kingdom); Journal Volume: 25
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; PROSTAGLANDINS; METABOLISM; ACUTE IRRADIATION; BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; DELAYED RADIATION EFFECTS; FIBROBLASTS; RADIOSENSITIVITY; X RADIATION; ACUTE EXPOSURE; ANIMAL CELLS; BIOLOGICAL EFFECTS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IRRADIATION; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture; 550500 - Metabolism
OSTI ID:
6936968
Research Organizations:
Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PLIRD
Submitting Site:
GBN
Size:
Pages: 587-590
Announcement Date:
Jul 01, 1988

Citation Formats

Walden, Jr, T L, Holahan, Jr, E V, and Catravas, G N. Development of a model system to study leukotriene-induced modification of radiation sensitivity in mammalian cells. United Kingdom: N. p., 1986. Web. doi:10.1016/0163-7827(86)90120-7.
Walden, Jr, T L, Holahan, Jr, E V, & Catravas, G N. Development of a model system to study leukotriene-induced modification of radiation sensitivity in mammalian cells. United Kingdom. doi:10.1016/0163-7827(86)90120-7.
Walden, Jr, T L, Holahan, Jr, E V, and Catravas, G N. 1986. "Development of a model system to study leukotriene-induced modification of radiation sensitivity in mammalian cells." United Kingdom. doi:10.1016/0163-7827(86)90120-7. https://www.osti.gov/servlets/purl/10.1016/0163-7827(86)90120-7.
@misc{etde_6936968,
title = {Development of a model system to study leukotriene-induced modification of radiation sensitivity in mammalian cells}
author = {Walden, Jr, T L, Holahan, Jr, E V, and Catravas, G N}
abstractNote = {Leukotrienes (LT) are an important class of biological mediators for which no information exists concerning their synthesis following a radiation insult or on their ability to modify cellular response to a subsequent radiation exposure. Results are presented which illustrate that the Chinese hamster lung fibroblast cell line, V79A03, is useful as a model system to study the metabolic fate of leukotrienes and the effect of LT on radiation sensitivity of mammalian cells in vitro. (U.K.).}
doi = {10.1016/0163-7827(86)90120-7}
journal = {Progr. Lipid Res.; (United Kingdom)}
volume = {25}
journal type = {AC}
place = {United Kingdom}
year = {1986}
month = {Jan}
}