You need JavaScript to view this

Early detection of drug-induced pneumonitis by gallium-67 lung scan in six patients with normal chest radiographs

Journal Article:

Abstract

Increased pulmonary accumulation of Gallium-67-citrate was observed in 6 patients (4 with malignant lymphoma, 1 with uterine cancer and 1 with acute myelocytic leukemia) preceding the appearance of any abnormal findings in both chest X-ray and blood gas data. All of them had received multiple courses of chemotherapy. In these patients, the anticancer drugs were administered for 13 to 22 weeks (mean 15 weeks). One patient with malignant lymphoma showed abnormal /sup 67/Ga lung uptake greater than hepatic activity, 3 patients (malignant lymphoma, 2 and uterine cancer, 1) visualized abnormal /sup 67/Ga lung uptake equal to hepatic activity and 2 cases (malignant lymphoma, 1 and acute myelocytic leukemia, 1) demonstrated abnormal accumulation of /sup 67/Ga in the lung greater than background activity. In 4 patients (3 with malignant lymphoma and 1 with uterine cancer) out of 6, transbronchial lung biopsy obtained after the /sup 67/Ga scans showed non-specific interstitial pneumonitis with infiltration of lymphocytes and macrophages compatible with drug-induced pneumonitis. In the other 2 patients, cytology and cultures were negative and follow up /sup 67/Ga lung scans revealed a reduction in intensity of uptake after treatment with corticosteroid. Therefore, we considered that the /sup 67/Ga lung scan was useful for  More>>
Authors:
Nakajima, H; Sawa, H; Takashima, S [1] 
  1. Osaka City Univ. (Japan). Hospital
Publication Date:
Jun 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-13-696271; EDB-82-165984
Resource Relation:
Journal Name: Kaku Igaku; (Japan); Journal Volume: 18:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; SIDE EFFECTS; GALLIUM 67; DIAGNOSTIC USES; LUNGS; SCINTISCANNING; PNEUMONITIS; DIAGNOSIS; BLEOMYCIN; CARCINOMAS; ENDOXAN; LYMPHOMAS; MYELOID LEUKEMIA; MYLERAN; ONCOVIN; UROGENITAL SYSTEM DISEASES; ALKALOIDS; ALKYLATING AGENTS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BETA DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GALLIUM ISOTOPES; HEMIC DISEASES; IMMUNOSUPPRESSIVE DRUGS; INTERMEDIATE MASS NUCLEI; ISOTOPES; LEUKEMIA; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RESPIRATORY SYSTEM; THERAPY; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6932068
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: KAIGB
Submitting Site:
HEDB
Size:
Pages: 583-590
Announcement Date:

Journal Article:

Citation Formats

Nakajima, H, Sawa, H, and Takashima, S. Early detection of drug-induced pneumonitis by gallium-67 lung scan in six patients with normal chest radiographs. Japan: N. p., 1981. Web.
Nakajima, H, Sawa, H, & Takashima, S. Early detection of drug-induced pneumonitis by gallium-67 lung scan in six patients with normal chest radiographs. Japan.
Nakajima, H, Sawa, H, and Takashima, S. 1981. "Early detection of drug-induced pneumonitis by gallium-67 lung scan in six patients with normal chest radiographs." Japan.
@misc{etde_6932068,
title = {Early detection of drug-induced pneumonitis by gallium-67 lung scan in six patients with normal chest radiographs}
author = {Nakajima, H, Sawa, H, and Takashima, S}
abstractNote = {Increased pulmonary accumulation of Gallium-67-citrate was observed in 6 patients (4 with malignant lymphoma, 1 with uterine cancer and 1 with acute myelocytic leukemia) preceding the appearance of any abnormal findings in both chest X-ray and blood gas data. All of them had received multiple courses of chemotherapy. In these patients, the anticancer drugs were administered for 13 to 22 weeks (mean 15 weeks). One patient with malignant lymphoma showed abnormal /sup 67/Ga lung uptake greater than hepatic activity, 3 patients (malignant lymphoma, 2 and uterine cancer, 1) visualized abnormal /sup 67/Ga lung uptake equal to hepatic activity and 2 cases (malignant lymphoma, 1 and acute myelocytic leukemia, 1) demonstrated abnormal accumulation of /sup 67/Ga in the lung greater than background activity. In 4 patients (3 with malignant lymphoma and 1 with uterine cancer) out of 6, transbronchial lung biopsy obtained after the /sup 67/Ga scans showed non-specific interstitial pneumonitis with infiltration of lymphocytes and macrophages compatible with drug-induced pneumonitis. In the other 2 patients, cytology and cultures were negative and follow up /sup 67/Ga lung scans revealed a reduction in intensity of uptake after treatment with corticosteroid. Therefore, we considered that the /sup 67/Ga lung scan was useful for early detection of drug-induced pneumonitis.}
journal = {Kaku Igaku; (Japan)}
volume = {18:5}
journal type = {AC}
place = {Japan}
year = {1981}
month = {Jun}
}