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Isotope release cytotoxicity assay applicable to human tumors: the use of 111-indium

Journal Article:

Abstract

We have demonstrated that human tumors can be labelled efficiently with the 111indium-oxine chelate. Subsequently, this isotope can be released by cytotoxic lymphoid cells. Both natural and induced cytotoxicity can be demonstrated utilizing this isotope release method. Because of the slow spontaneous release of 111indium and its efficient labelling of human tumor cells, this isotope release assay can be utilized in long-term cytotoxic assays in the study of human tumor immunology.
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
ERA-04-001471; EDB-78-125522
Resource Relation:
Journal Name: Oncology; (Switzerland); Journal Volume: 34:3
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; INDIUM 111; DIAGNOSTIC USES; NEOPLASMS; LABELLING; ANIMAL CELLS; CYTOLOGICAL TECHNIQUES; EXPERIMENTAL NEOPLASMS; IMMUNOLOGY; LYMPHOCYTES; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEUKOCYTES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; SOMATIC CELLS; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6930332
Research Organizations:
Wayne State Univ., Detroit
Country of Origin:
Switzerland
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ONCOB
Submitting Site:
TIC
Size:
Pages: 102-104
Announcement Date:

Journal Article:

Citation Formats

Frost, P, Wiltrout, R, Maciorowski, Z, and Rose, N R. Isotope release cytotoxicity assay applicable to human tumors: the use of 111-indium. Switzerland: N. p., 1977. Web.
Frost, P, Wiltrout, R, Maciorowski, Z, & Rose, N R. Isotope release cytotoxicity assay applicable to human tumors: the use of 111-indium. Switzerland.
Frost, P, Wiltrout, R, Maciorowski, Z, and Rose, N R. 1977. "Isotope release cytotoxicity assay applicable to human tumors: the use of 111-indium." Switzerland.
@misc{etde_6930332,
title = {Isotope release cytotoxicity assay applicable to human tumors: the use of 111-indium}
author = {Frost, P, Wiltrout, R, Maciorowski, Z, and Rose, N R}
abstractNote = {We have demonstrated that human tumors can be labelled efficiently with the 111indium-oxine chelate. Subsequently, this isotope can be released by cytotoxic lymphoid cells. Both natural and induced cytotoxicity can be demonstrated utilizing this isotope release method. Because of the slow spontaneous release of 111indium and its efficient labelling of human tumor cells, this isotope release assay can be utilized in long-term cytotoxic assays in the study of human tumor immunology.}
journal = {Oncology; (Switzerland)}
volume = {34:3}
journal type = {AC}
place = {Switzerland}
year = {1977}
month = {Jan}
}