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Cardiac ultrastructural changes in rats following 250 Gy whole body. gamma. -irradiation

Abstract

Sixteen rats were whole body irradiated with 250 Gy of /sup 60/Co ..gamma..-rays, killed at different intervals after exposure, and then observed by electron microscope. We found lysis of part of myofilaments in specimen obtained at 10 minutes after exposure, and resolution of Z-band at 30 minutes after exposure. These changes were more significant in sections at 12 hours postirradiation, but there also appeared cell regeneration at the same time. The vascular changes were more obvious with the endothelial cytoplasma projected in capillary lumen, nearly obstructing it. All of above described changes may be found in hematologic or intestinal forms of radiation sickness, but they must take place more late after exposure. In cardiovascular form, however, these changes were found as early as 10-30 minutes after exposure; this is a special feature helpful to diagnosis.
Publication Date:
Oct 01, 1985
Product Type:
Journal Article
Reference Number:
AIX-18-013170; EDB-87-034468
Resource Relation:
Journal Name: Zhonghua Fangshe Yixue Yu Fanghu Zazhi; (China); Journal Volume: 5:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MYOCARDIUM; MORPHOLOGICAL CHANGES; COBALT 60; ELECTRON MICROSCOPY; EXTERNAL IRRADIATION; GAMMA RADIATION; RADIATION INJURIES; RATS; TISSUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARDIOVASCULAR SYSTEM; COBALT ISOTOPES; ELECTROMAGNETIC RADIATION; HEART; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MICROSCOPY; MINUTES LIVING RADIOISOTOPES; MUSCLES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6914380
Research Organizations:
Fourth Military Medical Coll., PLA, Xian, SN, China
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: CODEN: ZFYZD
Submitting Site:
INIS
Size:
Pages: 329-330
Announcement Date:
Feb 01, 1987

Citation Formats

Yao, Guo, Mingyue, Zhu, and Zhiqin, Zhao. Cardiac ultrastructural changes in rats following 250 Gy whole body. gamma. -irradiation. China: N. p., 1985. Web.
Yao, Guo, Mingyue, Zhu, & Zhiqin, Zhao. Cardiac ultrastructural changes in rats following 250 Gy whole body. gamma. -irradiation. China.
Yao, Guo, Mingyue, Zhu, and Zhiqin, Zhao. 1985. "Cardiac ultrastructural changes in rats following 250 Gy whole body. gamma. -irradiation." China.
@misc{etde_6914380,
title = {Cardiac ultrastructural changes in rats following 250 Gy whole body. gamma. -irradiation}
author = {Yao, Guo, Mingyue, Zhu, and Zhiqin, Zhao}
abstractNote = {Sixteen rats were whole body irradiated with 250 Gy of /sup 60/Co ..gamma..-rays, killed at different intervals after exposure, and then observed by electron microscope. We found lysis of part of myofilaments in specimen obtained at 10 minutes after exposure, and resolution of Z-band at 30 minutes after exposure. These changes were more significant in sections at 12 hours postirradiation, but there also appeared cell regeneration at the same time. The vascular changes were more obvious with the endothelial cytoplasma projected in capillary lumen, nearly obstructing it. All of above described changes may be found in hematologic or intestinal forms of radiation sickness, but they must take place more late after exposure. In cardiovascular form, however, these changes were found as early as 10-30 minutes after exposure; this is a special feature helpful to diagnosis.}
journal = []
volume = {5:5}
journal type = {AC}
place = {China}
year = {1985}
month = {Oct}
}