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Delayed results of therapy of thyrotoxicosis with sup(131)I and posttherapeutic hypothyrosis

Abstract

A total of 1587 patients with thyrotoxicosis (1387 women and 266 men) were examined over time after /sup 131/I therapy. The radioactive drug was given once to 808 patients, two times to 337 patients, 3 times to 198 and 4 times to 82 patients. 669 patients received 74-185 MBq of /sup 131/I. 649 patients 222-370 MBq, 128 patients 407-555 MBq and 94 patients 592-740 MBq. The other 47 patients received /sup 131/I of higher activity. Posttherapeutic hypothyrosis was revealed in 5.4% of the cases. In half of the patients hypothyrosis developed after a single administration of /sup 131/I. In all the patients with posttherapeutic hypothyrosis, i.v. administration of thyroliberin resulted in a significant rise of the thyrotropin level indicating to great importance of this test. A follow up of such patients is necessary as hypothyrosis can develop at different time after treatment of thyrotoxicosis patients with /sup 131/I.
Publication Date:
Mar 01, 1986
Product Type:
Journal Article
Reference Number:
AIX-18-001873; EDB-87-025814
Resource Relation:
Journal Name: Med. Radiol.; (USSR); Journal Volume: 31:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HYPERTHYROIDISM; IODINE 131; RADIOTHERAPY; DELAYED RADIATION EFFECTS; GOITER; HYPOTHYROIDISM; PATIENTS; RADIOACTIVITY; SIDE EFFECTS; THYROID HORMONES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DAYS LIVING RADIOISOTOPES; DISEASES; ENDOCRINE DISEASES; HORMONES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; PEPTIDE HORMONES; RADIATION EFFECTS; RADIOISOTOPES; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
6905532
Research Organizations:
Nauchno-Issledovatelskij Inst Ehksperimental'noj i Klinicheskoj meditsiny, Riga, USSR
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: MERAA
Submitting Site:
INIS
Size:
Pages: 24-27
Announcement Date:
Feb 01, 1987

Citation Formats

Khelds, A O, Ozols, V K, and Shtelmane, I A. Delayed results of therapy of thyrotoxicosis with sup(131)I and posttherapeutic hypothyrosis. USSR: N. p., 1986. Web.
Khelds, A O, Ozols, V K, & Shtelmane, I A. Delayed results of therapy of thyrotoxicosis with sup(131)I and posttherapeutic hypothyrosis. USSR.
Khelds, A O, Ozols, V K, and Shtelmane, I A. 1986. "Delayed results of therapy of thyrotoxicosis with sup(131)I and posttherapeutic hypothyrosis." USSR.
@misc{etde_6905532,
title = {Delayed results of therapy of thyrotoxicosis with sup(131)I and posttherapeutic hypothyrosis}
author = {Khelds, A O, Ozols, V K, and Shtelmane, I A}
abstractNote = {A total of 1587 patients with thyrotoxicosis (1387 women and 266 men) were examined over time after /sup 131/I therapy. The radioactive drug was given once to 808 patients, two times to 337 patients, 3 times to 198 and 4 times to 82 patients. 669 patients received 74-185 MBq of /sup 131/I. 649 patients 222-370 MBq, 128 patients 407-555 MBq and 94 patients 592-740 MBq. The other 47 patients received /sup 131/I of higher activity. Posttherapeutic hypothyrosis was revealed in 5.4% of the cases. In half of the patients hypothyrosis developed after a single administration of /sup 131/I. In all the patients with posttherapeutic hypothyrosis, i.v. administration of thyroliberin resulted in a significant rise of the thyrotropin level indicating to great importance of this test. A follow up of such patients is necessary as hypothyrosis can develop at different time after treatment of thyrotoxicosis patients with /sup 131/I.}
journal = []
volume = {31:3}
journal type = {AC}
place = {USSR}
year = {1986}
month = {Mar}
}