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Lipid peroxide levels of serum lipoprotein fractions of diabetic patients with angiopathy and /sup 60/Co-irradiated rabbit

Journal Article:

Abstract

For a better understanding of the relationship between lipid peroxide (LPO) and vascular diseases, the author determined LPO levels and lipid contents of serum lipoprotein fractions of diabetics with angiopathy. The LPO level in high density lipoprotein (HDL) fraction of diabetic serum was significantly higher than that of normal serum whereas no significant increase was observed in the levels of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) fractions of diabetic serum. As to the ratios of LPO to total lipids in these lipoprotein fractions, it was found that the ratio in HDL fraction of the diabetics was markedly higher than that of the normals. These results suggest that the increase in LPO levels in the sera of diabetic patients is due to that in HDL fraction. To study further this problem, the author employed /sup 60/Co-irradiated rabbit as a model, since it was already reported that radiation affects lipid metabolism and LPO formation, and that it induces the development of atherosclerosis. Upon irradiation with /sup 60/Co ranging from 100R to 700R, serum LPO level of rabbit was significantly increased. Although elevation of LPO level was found in each serum lipoprotein fraction of VLDL, LDL and HDL, LPO  More>>
Authors:
Tsunekawa, Hiroshi [1] 
  1. Nagoya Univ. (Japan). Faculty of Medicine
Publication Date:
Sep 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-15-027762; EDB-84-095688
Resource Relation:
Journal Name: Nagoya Igaku; (Japan); Journal Volume: 105:1-2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; DIABETES MELLITUS; PATHOLOGY; LIPOPROTEINS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL LOCALIZATION; BIOLOGICAL MODELS; BLOOD SERUM; DIAGNOSIS; GAMMA RADIATION; KIDNEYS; LIVER; PATIENTS; RABBITS; RADIATION DOSES; RADIOINDUCTION; SPLEEN; VASCULAR DISEASES; WHOLE-BODY IRRADIATION; ANIMALS; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; DISEASES; DOSES; ELECTROMAGNETIC RADIATION; ENDOCRINE DISEASES; EXTERNAL IRRADIATION; GLANDS; IONIZING RADIATIONS; IRRADIATION; LIPIDS; MAMMALS; METABOLIC DISEASES; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIATION EFFECTS; RADIATIONS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 550900 - Pathology
OSTI ID:
6904211
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NAIGA
Submitting Site:
HEDB
Size:
Pages: 23-32
Announcement Date:

Journal Article:

Citation Formats

Tsunekawa, Hiroshi. Lipid peroxide levels of serum lipoprotein fractions of diabetic patients with angiopathy and /sup 60/Co-irradiated rabbit. Japan: N. p., 1982. Web.
Tsunekawa, Hiroshi. Lipid peroxide levels of serum lipoprotein fractions of diabetic patients with angiopathy and /sup 60/Co-irradiated rabbit. Japan.
Tsunekawa, Hiroshi. 1982. "Lipid peroxide levels of serum lipoprotein fractions of diabetic patients with angiopathy and /sup 60/Co-irradiated rabbit." Japan.
@misc{etde_6904211,
title = {Lipid peroxide levels of serum lipoprotein fractions of diabetic patients with angiopathy and /sup 60/Co-irradiated rabbit}
author = {Tsunekawa, Hiroshi}
abstractNote = {For a better understanding of the relationship between lipid peroxide (LPO) and vascular diseases, the author determined LPO levels and lipid contents of serum lipoprotein fractions of diabetics with angiopathy. The LPO level in high density lipoprotein (HDL) fraction of diabetic serum was significantly higher than that of normal serum whereas no significant increase was observed in the levels of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) fractions of diabetic serum. As to the ratios of LPO to total lipids in these lipoprotein fractions, it was found that the ratio in HDL fraction of the diabetics was markedly higher than that of the normals. These results suggest that the increase in LPO levels in the sera of diabetic patients is due to that in HDL fraction. To study further this problem, the author employed /sup 60/Co-irradiated rabbit as a model, since it was already reported that radiation affects lipid metabolism and LPO formation, and that it induces the development of atherosclerosis. Upon irradiation with /sup 60/Co ranging from 100R to 700R, serum LPO level of rabbit was significantly increased. Although elevation of LPO level was found in each serum lipoprotein fraction of VLDL, LDL and HDL, LPO level per lipid content was significantly increased only in HDL fraction. In the irradiated rabbit, significant elevation of the level of LPO was also observed in the liver, while no significant increase was found in the kidney and spleen. These results indicate that high level of LPO observed in the serum of irradiated rabbit would be the reflection of the increased LPO in the liver.}
journal = {Nagoya Igaku; (Japan)}
volume = {105:1-2}
journal type = {AC}
place = {Japan}
year = {1982}
month = {Sep}
}