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Inactivation of biological substances by local heating

Abstract

Mechanism of inactivation of biological substances caused by local heating was investigated. The effect of hot-zone formation by local heating on reaction of radicals was previously evaluated. The thermal increase in a hot zone due to low energy LET x-rays had little effect on reactibility of the radicals, but, in a hot zone caused by high energy LET x-rays, formed radicals seemed immediately react to active biological molecules to inactivate them. Direct thermal effect on biological molecules was analysed. Thermal increase in a hot zone may induce degenaration of biological molecules which seems to occur in a short time judged from the extension of a hot zone and the duration of high temperature.
Authors:
Saito, Masahiro [1] 
  1. Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Inst.
Publication Date:
Sep 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-15-033240; EDB-84-095750
Resource Relation:
Journal Name: Hoshasen Seibutsu Kenkyu; (Japan); Journal Volume: 17:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HYPERTHERMIA; BIOLOGICAL EFFECTS; BIOCHEMICAL REACTION KINETICS; BIOLOGICAL FUNCTIONS; DYNAMIC FUNCTION STUDIES; ENZYMES; INACTIVATION; MOLECULAR BIOLOGY; PROTEIN DENATURATION; RADICALS; TEMPERATURE DEPENDENCE; X RADIATION; BODY TEMPERATURE; ELECTROMAGNETIC RADIATION; FUNCTIONS; IONIZING RADIATIONS; KINETICS; RADIATIONS; REACTION KINETICS; 560200* - Thermal Effects
OSTI ID:
6903957
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: HSKEA
Submitting Site:
HEDB
Size:
Pages: 3-5
Announcement Date:
May 01, 1984

Citation Formats

Saito, Masahiro. Inactivation of biological substances by local heating. Japan: N. p., 1982. Web.
Saito, Masahiro. Inactivation of biological substances by local heating. Japan.
Saito, Masahiro. 1982. "Inactivation of biological substances by local heating." Japan.
@misc{etde_6903957,
title = {Inactivation of biological substances by local heating}
author = {Saito, Masahiro}
abstractNote = {Mechanism of inactivation of biological substances caused by local heating was investigated. The effect of hot-zone formation by local heating on reaction of radicals was previously evaluated. The thermal increase in a hot zone due to low energy LET x-rays had little effect on reactibility of the radicals, but, in a hot zone caused by high energy LET x-rays, formed radicals seemed immediately react to active biological molecules to inactivate them. Direct thermal effect on biological molecules was analysed. Thermal increase in a hot zone may induce degenaration of biological molecules which seems to occur in a short time judged from the extension of a hot zone and the duration of high temperature.}
journal = []
volume = {17:3}
journal type = {AC}
place = {Japan}
year = {1982}
month = {Sep}
}