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Study, development and clinical evaluation of a per-operative {gamma} imager; Etude, developpement et evaluation clinique d`un imageur {gamma} per-operatoire

Abstract

The precise localization and complete surgical ablation of tumors are one of the most important procedures in cancer treatment. In that context, the use, in operating room, of light hand-held detectors associated to radiopharmaceutical compounds for tumor labelling, plays a significant role in assisting surgeons in real-time detection of lesion. The POCI gamma imaging probe (Per-Operative Compact Imager), which is presented here, is precisely dedicated to improve the radio-guided operative cancer surgery efficiency by bringing a new tool discriminating between healthy and pathological tissues. To match the specifications of intra-operative detection, we chose to build our camera around an intensified position sensitive diode which appeared to be particularly suitable to achieve a high resolution small size imager. The optimal geometry of two gamma detection head modules, composed of parallel hole collimators and scintillation crystals, was then investigated by numerical simulations. From these technological solutions, a first prototype of POCI with a 24 mm diameter field of view has been developed. Its characterization has put forward a millimeter spatial resolution and a detection efficiency comparable to that of clinical gamma cameras and in agreement with the numerical predictions. Finally, in collaboration with Gustave Roussy, a first clinical evaluation of the POCI  More>>
Authors:
Menard, Laurent [1] 
  1. Inst. de Physique Nucleaire, Paris-11 Univ., 91 - Orsay (France)
Publication Date:
Jan 19, 1999
Product Type:
Thesis/Dissertation
Report Number:
IPNO-T-99-01
Reference Number:
SCA: 440101; PA: AIX-30:044664; EDB-99:102377; SN: 99002153186
Resource Relation:
Other Information: DN: 100 refs., 67 figs., 11 tabs.; TH: Theses (Ph.D); PBD: 19 Jan 1999
Subject:
44 INSTRUMENTATION, INCLUDING NUCLEAR AND PARTICLE DETECTORS; DISPLAY DEVICES; GAMMA RADIATION; IMAGE CONVERTERS; NEOPLASMS; POSITION SENSITIVE DETECTORS; RADIOPHARMACEUTICALS; SPATIAL RESOLUTION; SURGERY
OSTI ID:
690198
Research Organizations:
Inst. de Physique Nucleaire, Paris-11 Univ., 91 - Orsay (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
Other: ON: DE99635252; TRN: FR9903342044664
Availability:
INIS; OSTI as DE99635252
Submitting Site:
FRN
Size:
123 p.
Announcement Date:

Citation Formats

Menard, Laurent. Study, development and clinical evaluation of a per-operative {gamma} imager; Etude, developpement et evaluation clinique d`un imageur {gamma} per-operatoire. France: N. p., 1999. Web.
Menard, Laurent. Study, development and clinical evaluation of a per-operative {gamma} imager; Etude, developpement et evaluation clinique d`un imageur {gamma} per-operatoire. France.
Menard, Laurent. 1999. "Study, development and clinical evaluation of a per-operative {gamma} imager; Etude, developpement et evaluation clinique d`un imageur {gamma} per-operatoire." France.
@misc{etde_690198,
title = {Study, development and clinical evaluation of a per-operative {gamma} imager; Etude, developpement et evaluation clinique d`un imageur {gamma} per-operatoire}
author = {Menard, Laurent}
abstractNote = {The precise localization and complete surgical ablation of tumors are one of the most important procedures in cancer treatment. In that context, the use, in operating room, of light hand-held detectors associated to radiopharmaceutical compounds for tumor labelling, plays a significant role in assisting surgeons in real-time detection of lesion. The POCI gamma imaging probe (Per-Operative Compact Imager), which is presented here, is precisely dedicated to improve the radio-guided operative cancer surgery efficiency by bringing a new tool discriminating between healthy and pathological tissues. To match the specifications of intra-operative detection, we chose to build our camera around an intensified position sensitive diode which appeared to be particularly suitable to achieve a high resolution small size imager. The optimal geometry of two gamma detection head modules, composed of parallel hole collimators and scintillation crystals, was then investigated by numerical simulations. From these technological solutions, a first prototype of POCI with a 24 mm diameter field of view has been developed. Its characterization has put forward a millimeter spatial resolution and a detection efficiency comparable to that of clinical gamma cameras and in agreement with the numerical predictions. Finally, in collaboration with Gustave Roussy, a first clinical evaluation of the POCI camera has been performed for sentinel ganglion pre-operative localization in patients afflicted by malignant melanomas or breast cancers. The preliminary results have already shown that the performances of POCI are compatible with intraoperative imaging purposes and suggest how this camera can boost the success rate of tumor removal surgeries for other cancerous diseases. (author) 100 refs., 67 figs., 11 tabs.}
place = {France}
year = {1999}
month = {Jan}
}