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/sup 239/PuO/sub 2/ aerosol inhalation with emphasis on pulmonary connective tissue modifications

Journal Article:

Abstract

Inhalation studies were undertaken in which plutonium dioxide (/sup 239/PuO/sub 2/) was administered to either unanesthetized Wistar rats or anaesthetized baboons. In both groups of animals some deaths occurred from acute lung damage resulting from cell necrosis particularly to vascular tissue followed by alveolar oedema. At later stages, marked interstitial pneumonitis and interstitial fibrosis occurred and deaths resulted from respiratory insufficiency preceded by high arterial blood pCO/sub 2/ and low pO/sub 2/. In rats as many as 50% of the animals finally developed lung neoplasms but only two such tumors were found in baboons. Attempts were made to correlate biochemical parameters with observed tissue damage and animal mortality.
Publication Date:
Sep 01, 1975
Product Type:
Journal Article
Reference Number:
EDB-79-003810
Resource Relation:
Journal Name: Inhaled Part.; (United Kingdom); Journal Volume: 4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LUNGS; NEOPLASMS; PATHOLOGICAL CHANGES; PLUTONIUM 239; BIOLOGICAL RADIATION EFFECTS; INHALATION; PLUTONIUM DIOXIDE; PRIMATES; RADIATION INJURIES; RATS; ACTINIDE COMPOUNDS; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ANIMALS; BIOLOGICAL EFFECTS; BODY; CHALCOGENIDES; DISEASES; EVEN-ODD NUCLEI; HEAVY NUCLEI; INJURIES; INTAKE; ISOTOPES; MAMMALS; NUCLEI; ORGANS; OXIDES; OXYGEN COMPOUNDS; PLUTONIUM COMPOUNDS; PLUTONIUM ISOTOPES; PLUTONIUM OXIDES; RADIATION EFFECTS; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; TRANSURANIUM COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6893164
Research Organizations:
Commissariat a l'Energie Atomique, Montrouge, France
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IHPTB
Submitting Site:
TIC
Size:
Pages: 583-595
Announcement Date:

Journal Article:

Citation Formats

Metivier, H, Masse, R, Nobil'e, D, and Lafuma, J. /sup 239/PuO/sub 2/ aerosol inhalation with emphasis on pulmonary connective tissue modifications. United Kingdom: N. p., 1975. Web.
Metivier, H, Masse, R, Nobil'e, D, & Lafuma, J. /sup 239/PuO/sub 2/ aerosol inhalation with emphasis on pulmonary connective tissue modifications. United Kingdom.
Metivier, H, Masse, R, Nobil'e, D, and Lafuma, J. 1975. "/sup 239/PuO/sub 2/ aerosol inhalation with emphasis on pulmonary connective tissue modifications." United Kingdom.
@misc{etde_6893164,
title = {/sup 239/PuO/sub 2/ aerosol inhalation with emphasis on pulmonary connective tissue modifications}
author = {Metivier, H, Masse, R, Nobil'e, D, and Lafuma, J}
abstractNote = {Inhalation studies were undertaken in which plutonium dioxide (/sup 239/PuO/sub 2/) was administered to either unanesthetized Wistar rats or anaesthetized baboons. In both groups of animals some deaths occurred from acute lung damage resulting from cell necrosis particularly to vascular tissue followed by alveolar oedema. At later stages, marked interstitial pneumonitis and interstitial fibrosis occurred and deaths resulted from respiratory insufficiency preceded by high arterial blood pCO/sub 2/ and low pO/sub 2/. In rats as many as 50% of the animals finally developed lung neoplasms but only two such tumors were found in baboons. Attempts were made to correlate biochemical parameters with observed tissue damage and animal mortality.}
journal = {Inhaled Part.; (United Kingdom)}
volume = {4}
journal type = {AC}
place = {United Kingdom}
year = {1975}
month = {Sep}
}