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Kinetics of human lymphocyte division and chromosomal radiosensitivity

Journal Article:

Abstract

Human blood from normal donors was irradiated with 200 R during the G/sub 0/ phase, and the X-ray sensitivity of early and late dividing lymphocytes in culture was expressed as percentage of induced dicentrics. Cells in first or subsequent divisions were individualized by BrdU-Giemsa techniques. Lymphocytes in the first division at 40, 44 and 72 h after the start of culture had a lower sensitivity to radiation than lymphocytes making their first division at 48, 52 and 56 h. It was observed that: (a) the combination of radiation followed by BrdU did not increase the clastoyenic action of X-rays, (b)X-rays in the dose and duration used in our cultures did not increase the frequency of SCEs, and (c) minor changes in culture conditions probably influenced the frequency of SCEs.
Authors:
Bianchi, N O; Bianchi, M S; Larramendy, M [1] 
  1. Instituto Multidisciplinario de Biologia Celular, La Plata (Argentinia)
Publication Date:
Dec 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-11-546606; EDB-81-006869
Resource Relation:
Journal Name: Mutat. Res.; (Netherlands); Journal Volume: 63:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DICENTRIC CHROMOSOMES; RADIOSENSITIVITY; LYMPHOCYTES; BUDR; CHROMOSOMAL ABERRATIONS; KINETICS; MAN; MITOSIS; RADIATION DOSES; RESPONSE MODIFYING FACTORS; X RADIATION; ANIMAL CELLS; ANIMALS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; BROMOURACILS; CELL DIVISION; CHROMOSOMES; CONNECTIVE TISSUE CELLS; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IONIZING RADIATIONS; LEUKOCYTES; MAMMALS; MATERIALS; MUTATIONS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC BROMINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PRIMATES; PYRIMIDINES; RADIATIONS; RIBOSIDES; SOMATIC CELLS; URACILS; VERTEBRATES; 560122* - Radiation Effects on Cells- Internal Source- (-1987)
OSTI ID:
6880792
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MUREA
Submitting Site:
INIS
Size:
Pages: 317-324
Announcement Date:
Aug 01, 1980

Journal Article:

Citation Formats

Bianchi, N O, Bianchi, M S, and Larramendy, M. Kinetics of human lymphocyte division and chromosomal radiosensitivity. Netherlands: N. p., 1979. Web.
Bianchi, N O, Bianchi, M S, & Larramendy, M. Kinetics of human lymphocyte division and chromosomal radiosensitivity. Netherlands.
Bianchi, N O, Bianchi, M S, and Larramendy, M. 1979. "Kinetics of human lymphocyte division and chromosomal radiosensitivity." Netherlands.
@misc{etde_6880792,
title = {Kinetics of human lymphocyte division and chromosomal radiosensitivity}
author = {Bianchi, N O, Bianchi, M S, and Larramendy, M}
abstractNote = {Human blood from normal donors was irradiated with 200 R during the G/sub 0/ phase, and the X-ray sensitivity of early and late dividing lymphocytes in culture was expressed as percentage of induced dicentrics. Cells in first or subsequent divisions were individualized by BrdU-Giemsa techniques. Lymphocytes in the first division at 40, 44 and 72 h after the start of culture had a lower sensitivity to radiation than lymphocytes making their first division at 48, 52 and 56 h. It was observed that: (a) the combination of radiation followed by BrdU did not increase the clastoyenic action of X-rays, (b)X-rays in the dose and duration used in our cultures did not increase the frequency of SCEs, and (c) minor changes in culture conditions probably influenced the frequency of SCEs.}
journal = {Mutat. Res.; (Netherlands)}
volume = {63:2}
journal type = {AC}
place = {Netherlands}
year = {1979}
month = {Dec}
}