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Turnover of circulating hematopoietic stem cells

Journal Article:

Abstract

Short-term parabiosis of male and female CBA/CaJ mice was used to investigate the turnover of circulating hematopoietic stem cells. The change and subsequent disappearance of donor stem cells were monitored by spleen colony assay and chromosome analysis of individual colonies. The results revealed an exponential disappearance of pluripotent stem cells from blood with a characteristic half time of 1.7 h. Blood-borne stem cells were shown to be equilibrated with a subpopulation of marrow stem cells exhibiting a disappearance half time of 9.5 h. Splenectomy did not change the apparent rate of stem cell removal from the blood.
Publication Date:
Oct 01, 1979
Product Type:
Journal Article
Reference Number:
ERA-06-002957; EDB-80-129823
Resource Relation:
Journal Name: Exp. Hematol.; (Denmark); Journal Volume: 7:9
Subject:
59 BASIC BIOLOGICAL SCIENCES; HEMATOPOIETIC SYSTEM; CELL CYCLE; STEM CELLS; BIOASSAY; BLOOD; BONE MARROW; MICE; PARABIOSIS; SPLEEN; SPLEEN COLONY FORMATION; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; COLONY FORMATION; MAMMALS; MATERIALS; MOSAICISM; ORGANS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES; 550300* - Cytology; 551000 - Physiological Systems
OSTI ID:
6868544
Research Organizations:
Univ. of California, San Francisco
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EXHMA
Submitting Site:
TIC
Size:
Pages: 483-489
Announcement Date:

Journal Article:

Citation Formats

Dorie, M J, Maloney, M A, and Patt, H M. Turnover of circulating hematopoietic stem cells. Denmark: N. p., 1979. Web.
Dorie, M J, Maloney, M A, & Patt, H M. Turnover of circulating hematopoietic stem cells. Denmark.
Dorie, M J, Maloney, M A, and Patt, H M. 1979. "Turnover of circulating hematopoietic stem cells." Denmark.
@misc{etde_6868544,
title = {Turnover of circulating hematopoietic stem cells}
author = {Dorie, M J, Maloney, M A, and Patt, H M}
abstractNote = {Short-term parabiosis of male and female CBA/CaJ mice was used to investigate the turnover of circulating hematopoietic stem cells. The change and subsequent disappearance of donor stem cells were monitored by spleen colony assay and chromosome analysis of individual colonies. The results revealed an exponential disappearance of pluripotent stem cells from blood with a characteristic half time of 1.7 h. Blood-borne stem cells were shown to be equilibrated with a subpopulation of marrow stem cells exhibiting a disappearance half time of 9.5 h. Splenectomy did not change the apparent rate of stem cell removal from the blood.}
journal = {Exp. Hematol.; (Denmark)}
volume = {7:9}
journal type = {AC}
place = {Denmark}
year = {1979}
month = {Oct}
}