You need JavaScript to view this

A fundamental study of immunoscintigraphy with sup 131 I-labeled anti-CA 19-9 and anti-CEA monoclonal antibodies; Imaging of tumor-bearing mice by IMACIS-1 and cell ELISA with human tumor cells

Journal Article:

Abstract

A study was made on 2 types of {sup 131}I-labeled anti-CA 19-9 and anti-CEA mouse monoclonal antibodies (IMACIS-1) against human cancer related antigen as to their usefulness in radioimmunoimaging. Tumor-bearing nude mice were used for comparison. The transplanted tumors (SW948, COLO 201) were clearly visualized 48-72 hours after administration of IMACIS-1. Tumor/blood ratio 72 hours after administration: 8.69 in COLO 201 and 5.70 in SW948, showing ca. 10-15 times as high as those in PC-3 and HEp-2. IMACIS-1 therefore is considered useful in radioimmunoimaging of cancer. Analysis was made by in vitro cell ELISA. As a result, both of the cells specifically reacted with anti-CA 19-9 but not anti-CEA. (author).
Authors:
Nogami, Toshihiko; Miura, Hiroshi; Ohmi, Shoichi; Kazahaya, Yasuhiro [1] 
  1. CIS DIAGNOSTIC K.K., Chiba (Japan)
Publication Date:
May 01, 1990
Product Type:
Journal Article
Reference Number:
JPN-90-008318; EDB-90-148846
Resource Relation:
Journal Name: Kaku Igaku (Japanese Journal of Nuclear Medicine); (Japan); Journal Volume: 27:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; EXPERIMENTAL NEOPLASMS; RADIOIMMUNODETECTION; CARCINOMAS; IODINE 125; IODINE 131; MICE; MONOCLONAL ANTIBODIES; TISSUE DISTRIBUTION; TUMOR CELLS; ANIMAL CELLS; ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; RODENTS; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6867946
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0022-7854; CODEN: KAIGB
Submitting Site:
JPN
Size:
Pages: 427-436
Announcement Date:

Journal Article:

Citation Formats

Nogami, Toshihiko, Miura, Hiroshi, Ohmi, Shoichi, and Kazahaya, Yasuhiro. A fundamental study of immunoscintigraphy with sup 131 I-labeled anti-CA 19-9 and anti-CEA monoclonal antibodies; Imaging of tumor-bearing mice by IMACIS-1 and cell ELISA with human tumor cells. Japan: N. p., 1990. Web.
Nogami, Toshihiko, Miura, Hiroshi, Ohmi, Shoichi, & Kazahaya, Yasuhiro. A fundamental study of immunoscintigraphy with sup 131 I-labeled anti-CA 19-9 and anti-CEA monoclonal antibodies; Imaging of tumor-bearing mice by IMACIS-1 and cell ELISA with human tumor cells. Japan.
Nogami, Toshihiko, Miura, Hiroshi, Ohmi, Shoichi, and Kazahaya, Yasuhiro. 1990. "A fundamental study of immunoscintigraphy with sup 131 I-labeled anti-CA 19-9 and anti-CEA monoclonal antibodies; Imaging of tumor-bearing mice by IMACIS-1 and cell ELISA with human tumor cells." Japan.
@misc{etde_6867946,
title = {A fundamental study of immunoscintigraphy with sup 131 I-labeled anti-CA 19-9 and anti-CEA monoclonal antibodies; Imaging of tumor-bearing mice by IMACIS-1 and cell ELISA with human tumor cells}
author = {Nogami, Toshihiko, Miura, Hiroshi, Ohmi, Shoichi, and Kazahaya, Yasuhiro}
abstractNote = {A study was made on 2 types of {sup 131}I-labeled anti-CA 19-9 and anti-CEA mouse monoclonal antibodies (IMACIS-1) against human cancer related antigen as to their usefulness in radioimmunoimaging. Tumor-bearing nude mice were used for comparison. The transplanted tumors (SW948, COLO 201) were clearly visualized 48-72 hours after administration of IMACIS-1. Tumor/blood ratio 72 hours after administration: 8.69 in COLO 201 and 5.70 in SW948, showing ca. 10-15 times as high as those in PC-3 and HEp-2. IMACIS-1 therefore is considered useful in radioimmunoimaging of cancer. Analysis was made by in vitro cell ELISA. As a result, both of the cells specifically reacted with anti-CA 19-9 but not anti-CEA. (author).}
journal = {Kaku Igaku (Japanese Journal of Nuclear Medicine); (Japan)}
volume = {27:5}
journal type = {AC}
place = {Japan}
year = {1990}
month = {May}
}