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Comparative action spectra for pyrimidine dimer formation in Cloudman S91 mouse melanoma and EMT6 mouse mammary carcinoma cells

Abstract

Pyrimidine dimer formation in melanotic mouse melanoma cells, Cloudman S91H-, and in mouse mammary carcinoma cells, EMT6, was compared as a function of wavelength by irradiating equal numbers of cells from the two cell lines simultaneously. More dimers were formed in EMT6 than in S91H- by light of wavelengths less than 289nm, while light of higher wavelengths caused equivalent dimer formation, as measured by the Micrococcus luteus UV-endonuclease assay. The cells of S91H- are lightly melanotic, yet shielding at lower wavelengths is considerable. It is speculated that melanin pigmentation arose by selection during an evolutionary period when UV-C light reaching the earth's surface was significantly greater than it is today.
Authors:
Hill, H Z; [1]  Setlow, R B [2] 
  1. New Jersey, Medical School, Newark (USA)
  2. Brookhaven National Lab., Upton, NY (USA)
Publication Date:
May 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-13-713900; EDB-83-028071
Resource Relation:
Journal Name: Photochem. Photobiol.; (United Kingdom); Journal Volume: 35:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; BIOLOGICAL RADIATION EFFECTS; MELANIN; ORIGIN; TUMOR CELLS; ULTRAVIOLET RADIATION; MUTAGENESIS; CARCINOMAS; CELL CULTURES; DIMERS; FREQUENCY DEPENDENCE; MELANOMAS; MICE; PHOTOCHEMISTRY; PYRIMIDINES; ANIMAL CELLS; ANIMALS; AZINES; BIOLOGICAL EFFECTS; CHEMISTRY; DISEASES; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; MAMMALS; NEOPLASMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PIGMENTS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
6867264
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PHCBA
Submitting Site:
HEDB
Size:
Pages: 681-684
Announcement Date:

Citation Formats

Hill, H Z, and Setlow, R B. Comparative action spectra for pyrimidine dimer formation in Cloudman S91 mouse melanoma and EMT6 mouse mammary carcinoma cells. United Kingdom: N. p., 1982. Web. doi:10.1111/j.1751-1097.1982.tb02629.x.
Hill, H Z, & Setlow, R B. Comparative action spectra for pyrimidine dimer formation in Cloudman S91 mouse melanoma and EMT6 mouse mammary carcinoma cells. United Kingdom. doi:10.1111/j.1751-1097.1982.tb02629.x.
Hill, H Z, and Setlow, R B. 1982. "Comparative action spectra for pyrimidine dimer formation in Cloudman S91 mouse melanoma and EMT6 mouse mammary carcinoma cells." United Kingdom. doi:10.1111/j.1751-1097.1982.tb02629.x. https://www.osti.gov/servlets/purl/10.1111/j.1751-1097.1982.tb02629.x.
@misc{etde_6867264,
title = {Comparative action spectra for pyrimidine dimer formation in Cloudman S91 mouse melanoma and EMT6 mouse mammary carcinoma cells}
author = {Hill, H Z, and Setlow, R B}
abstractNote = {Pyrimidine dimer formation in melanotic mouse melanoma cells, Cloudman S91H-, and in mouse mammary carcinoma cells, EMT6, was compared as a function of wavelength by irradiating equal numbers of cells from the two cell lines simultaneously. More dimers were formed in EMT6 than in S91H- by light of wavelengths less than 289nm, while light of higher wavelengths caused equivalent dimer formation, as measured by the Micrococcus luteus UV-endonuclease assay. The cells of S91H- are lightly melanotic, yet shielding at lower wavelengths is considerable. It is speculated that melanin pigmentation arose by selection during an evolutionary period when UV-C light reaching the earth's surface was significantly greater than it is today.}
doi = {10.1111/j.1751-1097.1982.tb02629.x}
journal = {Photochem. Photobiol.; (United Kingdom)}
volume = {35:5}
journal type = {AC}
place = {United Kingdom}
year = {1982}
month = {May}
}