You need JavaScript to view this

Effects of cancer, radiotherapy and cytotoxic drugs on intestinal structure and function

Abstract

Intestinal malabsorption and the structural changes in the small intestine in relation to cancer, radiotherapy and cytotoxic drugs are reviewed. Primary intestinal malignancies are often associated with malabsorption; further studies have shown that tumours outside the gastrointestinal tract may also be accompanied by changes in intestinal structure resulting in malabsorption. Abdominal radiotherapy of cancer patients has been shown to result in ultrastructural changes in the small intestine, a decrease in intestinal enzyme activity and malabsorption of nutrients. The effects of cytotoxic drugs on the small intestinal structure and function are reviewed in more detail. The drugs discussed include the alkylating agents such as nitrogen mustard, cyclophosphamide, iphosphamide, 1,3-bis (2-chloroethyl)-1-nitrosourea and 1(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. The effects of antimetabolites such as aminopterin, methotrexate, 5-fluoracil, cytosine arabinoside and 6-mercaptorpurine are also reviewed. Other drugs discussed were adriamycin, vincrinstine sulfate, vinblastine and hydroxyurea. Studies of the effects of combination chemotherapy on small intestinal structure and function are also described. It is concluded that chemotherapeutic drugs and radiation therapy may aggravate a malabsorptive state in view of their toxicity to the small intestinal cell, or may by themselves be responsible for malabsorption with resultant increase in cachexia and weight loss.
Authors:
Shaw, M T; Spector, M H; Ladman, A J [1] 
  1. New Mexico Univ., Albuquerque (USA)
Publication Date:
Sep 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-11-517309; EDB-80-130201
Resource Relation:
Journal Name: Cancer Treat. Rev.; (United Kingdom); Journal Volume: 6:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHEMOTHERAPY; SIDE EFFECTS; SMALL INTESTINE; ULTRASTRUCTURAL CHANGES; ALKYLATING AGENTS; AMINOPTERIN; ANTIBIOTICS; DELAYED RADIATION EFFECTS; ENDOXAN; FLUOROURACILS; INTESTINAL ABSORPTION; MERCAPTOPURINE; METHOTREXATE; NEOPLASMS; NITROGEN MUSTARD; ONCOVIN; RADIOTHERAPY; UREA; VINBLASTINE; ABSORPTION; ALKALOIDS; AMIDES; AMINES; ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; AZOLES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARBONIC ACID DERIVATIVES; DIGESTIVE SYSTEM; DISEASES; DRUGS; GASTROINTESTINAL TRACT; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; INTESTINES; MEDICINE; MORPHOLOGICAL CHANGES; NUCLEAR MEDICINE; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PTERIDINES; PURINES; PYRIMIDINES; PYRROLES; RADIATION EFFECTS; RADIOLOGY; THERAPY; THIOLS; UPTAKE; URACILS; 560151* - Radiation Effects on Animals- Man; 560122 - Radiation Effects on Cells- Internal Source- (-1987)
OSTI ID:
6865971
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CTRED
Submitting Site:
INIS
Size:
Pages: 141-151
Announcement Date:

Citation Formats

Shaw, M T, Spector, M H, and Ladman, A J. Effects of cancer, radiotherapy and cytotoxic drugs on intestinal structure and function. United Kingdom: N. p., 1979. Web. doi:10.1016/S0305-7372(79)80066-3.
Shaw, M T, Spector, M H, & Ladman, A J. Effects of cancer, radiotherapy and cytotoxic drugs on intestinal structure and function. United Kingdom. doi:10.1016/S0305-7372(79)80066-3.
Shaw, M T, Spector, M H, and Ladman, A J. 1979. "Effects of cancer, radiotherapy and cytotoxic drugs on intestinal structure and function." United Kingdom. doi:10.1016/S0305-7372(79)80066-3. https://www.osti.gov/servlets/purl/10.1016/S0305-7372(79)80066-3.
@misc{etde_6865971,
title = {Effects of cancer, radiotherapy and cytotoxic drugs on intestinal structure and function}
author = {Shaw, M T, Spector, M H, and Ladman, A J}
abstractNote = {Intestinal malabsorption and the structural changes in the small intestine in relation to cancer, radiotherapy and cytotoxic drugs are reviewed. Primary intestinal malignancies are often associated with malabsorption; further studies have shown that tumours outside the gastrointestinal tract may also be accompanied by changes in intestinal structure resulting in malabsorption. Abdominal radiotherapy of cancer patients has been shown to result in ultrastructural changes in the small intestine, a decrease in intestinal enzyme activity and malabsorption of nutrients. The effects of cytotoxic drugs on the small intestinal structure and function are reviewed in more detail. The drugs discussed include the alkylating agents such as nitrogen mustard, cyclophosphamide, iphosphamide, 1,3-bis (2-chloroethyl)-1-nitrosourea and 1(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. The effects of antimetabolites such as aminopterin, methotrexate, 5-fluoracil, cytosine arabinoside and 6-mercaptorpurine are also reviewed. Other drugs discussed were adriamycin, vincrinstine sulfate, vinblastine and hydroxyurea. Studies of the effects of combination chemotherapy on small intestinal structure and function are also described. It is concluded that chemotherapeutic drugs and radiation therapy may aggravate a malabsorptive state in view of their toxicity to the small intestinal cell, or may by themselves be responsible for malabsorption with resultant increase in cachexia and weight loss.}
doi = {10.1016/S0305-7372(79)80066-3}
journal = {Cancer Treat. Rev.; (United Kingdom)}
volume = {6:3}
journal type = {AC}
place = {United Kingdom}
year = {1979}
month = {Sep}
}