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Development of delayed radiation necrosis. Case report

Journal Article:

Abstract

The authors discussed the developing process of delayed radiation necrosis of the brain from the case of a 42-year-old female who developed intracranial hypertension and left hemiparesis 5 and a half years after radiotherapy for pituitary adenoma. The initial sign of radiation necrosis was from a CT scan taken 3 and a half years after radiotherapy showing an irregular low density lesion in the right temporal lobe. CT scan 2 years later demonstrated displacement of the midline structures to the left and a larger low density lesion with partially high density in the right MCA territory that was enhanced with intravenous contrast medium. Recovery after a right temporal lobectomy and administration of steroid hormone were uneventful. Eight months later there were no signs of raised intracranial pressure nor of neurological deficits. Tissues obtained from the right temporal lobe at lobectomy revealed the characteristic changes of delayed radiation necrosis; a mixture of fresh, recent, and old vascular lesions in the same specimen. From these findings, it was speculated that delayed radiation necrosis might initially occur within several years after radiotherapy and might gradually take a progressive and extended course, even in cases whose clinical symptoms develop much later.
Authors:
Ohara, ShigFeki; Takagi, Terumasa; [1]  Shibata, Taichiro; Nagai, Hajime
  1. Meitetsu Hospital, Nagoya (Japan)
Publication Date:
Apr 01, 1983
Product Type:
Journal Article
Reference Number:
AIX-15-052465; EDB-84-151248
Resource Relation:
Journal Name: Neurol. Med.-Chir.; (Japan); Journal Volume: 23:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; DELAYED RADIATION EFFECTS; RADIATION INJURIES; PITUITARY GLAND; RADIOTHERAPY; SIDE EFFECTS; ADENOMAS; CAT SCANNING; DIAGNOSIS; GAMMA RADIATION; HYPERTENSION; NECROSIS; PATIENTS; SURGERY; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTROMAGNETIC RADIATION; ENDOCRINE GLANDS; GLANDS; INJURIES; IONIZING RADIATIONS; MEDICINE; NEOPLASMS; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; SYMPTOMS; THERAPY; TOMOGRAPHY; VASCULAR DISEASES; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
6864331
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NMCHB
Submitting Site:
HEDB
Size:
Pages: 295-300
Announcement Date:
Aug 01, 1984

Journal Article:

Citation Formats

Ohara, ShigFeki, Takagi, Terumasa, Shibata, Taichiro, and Nagai, Hajime. Development of delayed radiation necrosis. Case report. Japan: N. p., 1983. Web. doi:10.2176/nmc.23.295.
Ohara, ShigFeki, Takagi, Terumasa, Shibata, Taichiro, & Nagai, Hajime. Development of delayed radiation necrosis. Case report. Japan. doi:10.2176/nmc.23.295.
Ohara, ShigFeki, Takagi, Terumasa, Shibata, Taichiro, and Nagai, Hajime. 1983. "Development of delayed radiation necrosis. Case report." Japan. doi:10.2176/nmc.23.295. https://www.osti.gov/servlets/purl/10.2176/nmc.23.295.
@misc{etde_6864331,
title = {Development of delayed radiation necrosis. Case report}
author = {Ohara, ShigFeki, Takagi, Terumasa, Shibata, Taichiro, and Nagai, Hajime}
abstractNote = {The authors discussed the developing process of delayed radiation necrosis of the brain from the case of a 42-year-old female who developed intracranial hypertension and left hemiparesis 5 and a half years after radiotherapy for pituitary adenoma. The initial sign of radiation necrosis was from a CT scan taken 3 and a half years after radiotherapy showing an irregular low density lesion in the right temporal lobe. CT scan 2 years later demonstrated displacement of the midline structures to the left and a larger low density lesion with partially high density in the right MCA territory that was enhanced with intravenous contrast medium. Recovery after a right temporal lobectomy and administration of steroid hormone were uneventful. Eight months later there were no signs of raised intracranial pressure nor of neurological deficits. Tissues obtained from the right temporal lobe at lobectomy revealed the characteristic changes of delayed radiation necrosis; a mixture of fresh, recent, and old vascular lesions in the same specimen. From these findings, it was speculated that delayed radiation necrosis might initially occur within several years after radiotherapy and might gradually take a progressive and extended course, even in cases whose clinical symptoms develop much later.}
doi = {10.2176/nmc.23.295}
journal = {Neurol. Med.-Chir.; (Japan)}
volume = {23:4}
journal type = {AC}
place = {Japan}
year = {1983}
month = {Apr}
}