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Effect of antibiotics and bifidobacterial preparations on the intestinal microflora in mice irradiated with gamma quanta

Journal Article:

Abstract

Mice weighing 19-20 g have been exposed to the dose of 700 R and devided into 3 groups. During the first five days animals of the first group received antibiotics perorally - 40 units phenoxypenicillin, 30 units oxytetracycline, 40 units streptomicine. On the 6th, 10th and 15th days after irradiation the bifidobacterium preparation (75-41 strain) has been introduced perorally in the amount of 5x10/sup 8/ cells. Animals of the second group have received antibiotics alone in the same period as mice of the first group but the sterile physiological solution has been introduced instead of bifidobacteria. The sterile physiological solution has been perorally introduced to animals of the third group instead of antibiotics and bifidobacteria. The complex treatment has lead to the increase of survival percentage as compared with animals which have not been treated. The normalization of the intestines microbic landscape is observed in irradiated mice, subjected to treatment with antibiotics and bifidobacteria. It is expressed in a considerable reduction in the amount of clostridium, enterococci, intestinal bacilli and proteus as compared with the amount of these microbes in the intestines of non-treated mice. At the same time, a certain increase of lactobacilli amount to the level characteristic of  More>>
Publication Date:
Jul 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-584973; EDB-81-048010
Resource Relation:
Journal Name: Zh. Mikrobiol., Epidemiol. Immunobiol.; (USSR); Journal Volume: 7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; POST-IRRADIATION THERAPY; ANTIBIOTICS; BACTERIA; GAMMA RADIATION; INTESTINES; MICE; ORAL ADMINISTRATION; SURVIVAL CURVES; TIME DEPENDENCE; ANIMALS; ANTI-INFECTIVE AGENTS; BODY; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; GASTROINTESTINAL TRACT; IONIZING RADIATIONS; MAMMALS; MICROORGANISMS; ORGANS; RADIATIONS; RODENTS; THERAPY; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 560114 - Radiation Effects on Biochemicals- In Animals- (-1987)
OSTI ID:
6863871
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: ZMEIA
Submitting Site:
INIS
Size:
Pages: 25-29
Announcement Date:
Mar 01, 1981

Journal Article:

Citation Formats

Korshunov, V M, Pinegin, B V, Mal'tsev, V N, Kissina, E V, Ikonnikova, T B, Goncharova, G I, Lyannaya, A I, Institut Biofiziki, Moscow (USSR), and Akademiya Meditsinskikh Nauk SSSR, Moscow. Inst. Ehpidemiologii i Mikrobiologii). Effect of antibiotics and bifidobacterial preparations on the intestinal microflora in mice irradiated with gamma quanta. USSR: N. p., 1980. Web.
Korshunov, V M, Pinegin, B V, Mal'tsev, V N, Kissina, E V, Ikonnikova, T B, Goncharova, G I, Lyannaya, A I, Institut Biofiziki, Moscow (USSR), & Akademiya Meditsinskikh Nauk SSSR, Moscow. Inst. Ehpidemiologii i Mikrobiologii). Effect of antibiotics and bifidobacterial preparations on the intestinal microflora in mice irradiated with gamma quanta. USSR.
Korshunov, V M, Pinegin, B V, Mal'tsev, V N, Kissina, E V, Ikonnikova, T B, Goncharova, G I, Lyannaya, A I, Institut Biofiziki, Moscow (USSR), and Akademiya Meditsinskikh Nauk SSSR, Moscow. Inst. Ehpidemiologii i Mikrobiologii). 1980. "Effect of antibiotics and bifidobacterial preparations on the intestinal microflora in mice irradiated with gamma quanta." USSR.
@misc{etde_6863871,
title = {Effect of antibiotics and bifidobacterial preparations on the intestinal microflora in mice irradiated with gamma quanta}
author = {Korshunov, V M, Pinegin, B V, Mal'tsev, V N, Kissina, E V, Ikonnikova, T B, Goncharova, G I, Lyannaya, A I, Institut Biofiziki, Moscow (USSR), and Akademiya Meditsinskikh Nauk SSSR, Moscow. Inst. Ehpidemiologii i Mikrobiologii)}
abstractNote = {Mice weighing 19-20 g have been exposed to the dose of 700 R and devided into 3 groups. During the first five days animals of the first group received antibiotics perorally - 40 units phenoxypenicillin, 30 units oxytetracycline, 40 units streptomicine. On the 6th, 10th and 15th days after irradiation the bifidobacterium preparation (75-41 strain) has been introduced perorally in the amount of 5x10/sup 8/ cells. Animals of the second group have received antibiotics alone in the same period as mice of the first group but the sterile physiological solution has been introduced instead of bifidobacteria. The sterile physiological solution has been perorally introduced to animals of the third group instead of antibiotics and bifidobacteria. The complex treatment has lead to the increase of survival percentage as compared with animals which have not been treated. The normalization of the intestines microbic landscape is observed in irradiated mice, subjected to treatment with antibiotics and bifidobacteria. It is expressed in a considerable reduction in the amount of clostridium, enterococci, intestinal bacilli and proteus as compared with the amount of these microbes in the intestines of non-treated mice. At the same time, a certain increase of lactobacilli amount to the level characteristic of lactobacilli in the intestinal tract of non-treated animals is observed in the intestines of irradiated and treated mice.}
journal = {Zh. Mikrobiol., Epidemiol. Immunobiol.; (USSR)}
volume = {7}
journal type = {AC}
place = {USSR}
year = {1980}
month = {Jul}
}