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Regional cerebral blood flow in Parkinson's disease by [sup 123]I-IMP SPECT

Journal Article:

Abstract

Regional cerebral blood flow (rCBF) was evaluated in 63 patients with Parkinson's disease (PD) by single-photon emission computed tomography (SPECT) using N-isopropyl-p-[sup 123]I-iodoamphetamine ([sup 123]I-IMP) as a tracer. Evaluation of the SPECT images was performed in accordance with the rCBF quantification method using a microsphere model. Patients in stage IV demonstrated significantly lower rCBF than those in stage II at the frontal, temporal, parietal, occipital regions and in the thalamus and cerebellum. Subjects with mental symptoms demonstrated decreased rCBF in every region in the brain. The present study indicates that clinical exacerbation and manifestation of dementia and other psychiatric symptoms in Parkinson's disease are associated with decreased blood flow in various brain regions. (author).
Authors:
Kitamura, Yoshihiro [1] 
  1. Okayama Univ. (Japan). School of Medicine
Publication Date:
Jun 01, 1994
Product Type:
Journal Article
Reference Number:
JPN-94-009306; EDB-94-155127
Resource Relation:
Journal Name: Okayama Igakkai Zasshi (Journal of the Okayama Medical Society); (Japan); Journal Volume: 106:5-6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; BEHAVIOR; BENZEDRINE; BLOOD FLOW; CEREBELLUM; IODINE 123; MENTAL DISORDERS; THALAMUS; UPTAKE; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6862106
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0030-1558; CODEN: OIZAAV
Submitting Site:
JPN
Size:
Pages: 443-450
Announcement Date:

Journal Article:

Citation Formats

Kitamura, Yoshihiro. Regional cerebral blood flow in Parkinson's disease by [sup 123]I-IMP SPECT. Japan: N. p., 1994. Web.
Kitamura, Yoshihiro. Regional cerebral blood flow in Parkinson's disease by [sup 123]I-IMP SPECT. Japan.
Kitamura, Yoshihiro. 1994. "Regional cerebral blood flow in Parkinson's disease by [sup 123]I-IMP SPECT." Japan.
@misc{etde_6862106,
title = {Regional cerebral blood flow in Parkinson's disease by [sup 123]I-IMP SPECT}
author = {Kitamura, Yoshihiro}
abstractNote = {Regional cerebral blood flow (rCBF) was evaluated in 63 patients with Parkinson's disease (PD) by single-photon emission computed tomography (SPECT) using N-isopropyl-p-[sup 123]I-iodoamphetamine ([sup 123]I-IMP) as a tracer. Evaluation of the SPECT images was performed in accordance with the rCBF quantification method using a microsphere model. Patients in stage IV demonstrated significantly lower rCBF than those in stage II at the frontal, temporal, parietal, occipital regions and in the thalamus and cerebellum. Subjects with mental symptoms demonstrated decreased rCBF in every region in the brain. The present study indicates that clinical exacerbation and manifestation of dementia and other psychiatric symptoms in Parkinson's disease are associated with decreased blood flow in various brain regions. (author).}
journal = {Okayama Igakkai Zasshi (Journal of the Okayama Medical Society); (Japan)}
volume = {106:5-6}
journal type = {AC}
place = {Japan}
year = {1994}
month = {Jun}
}