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Late vascular effects of whole brain X-irradiation in the mouse

Journal Article:

Abstract

The whole brains of mice were irradiated with 250kVp X-rays at 120 rads min/sup -1/ (1.6 mm Cu HVL, TSD 50 cm), and a histological study was carried out. The dose range of X-irradiation was from 1,300 to 2,500 rads, i.e., 1,300, 1,500, 1,750, 2,000, and 2,500 rads. Eighty-six mice were used for histological examination. For microscopic examination, the mice were killed at regular postirradiation intervals between 15 and 20, 31 and 40, 41 and 50, 51 and 60, 61 and 70, 71 and 80, 81 and 90, 139 and 177 weeks. The brains were removed immediately thereafter, fixed in Bouin's solution, and embedded in paraffin. A histological examination was performed by a morphometric estimation of vascular lesions, in which the degree of the damage to the arterial system was scored in whole serial brain section. Necrosis (encephalomalacia), atrophy, cell infiltration, and telangiectactic vascular change of the brain, caused as a result of the fibrinoid necrosis of the large arteries, were observed. Dose-dependent incidence of the fibrinoid necrosis increased between 41 and 87 weeks after irradiation. Mean score of fibrinoid necrosis increased dose dependently approximately 60 weeks after irradiation. It is suggested that scores of large vessel damage do relate  More>>
Authors:
Yoshii, Y; [1]  Phillips, T L [2] 
  1. Tsukuba Univ., Sakma, Ibaraki (Japan). Inst. of Clinical Medicine
  2. California Univ., San Francisco (USA). Dept. of Radiation Oncology
Publication Date:
Jan 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-14-717262; EDB-83-036798
Resource Relation:
Journal Name: Acta Neurochir.; (Austria); Journal Volume: 64:1-2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD VESSELS; DELAYED RADIATION EFFECTS; BRAIN; EXPERIMENTAL DATA; HISTOLOGY; LATENCY PERIOD; LOCAL IRRADIATION; MICE; NECROSIS; NERVOUS SYSTEM DISEASES; RADIATION DOSES; RADIATION EFFECTS; RADIATIONS; TIME DEPENDENCE; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DATA; DISEASES; DOSES; INFORMATION; IRRADIATION; MAMMALS; NERVOUS SYSTEM; NUMERICAL DATA; ORGANS; PATHOLOGICAL CHANGES; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6852749
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ACNUA
Submitting Site:
HEDB
Size:
Pages: 87-102
Announcement Date:
Jan 01, 1983

Journal Article:

Citation Formats

Yoshii, Y, and Phillips, T L. Late vascular effects of whole brain X-irradiation in the mouse. Austria: N. p., 1982. Web. doi:10.1007/BF01405622.
Yoshii, Y, & Phillips, T L. Late vascular effects of whole brain X-irradiation in the mouse. Austria. doi:10.1007/BF01405622.
Yoshii, Y, and Phillips, T L. 1982. "Late vascular effects of whole brain X-irradiation in the mouse." Austria. doi:10.1007/BF01405622. https://www.osti.gov/servlets/purl/10.1007/BF01405622.
@misc{etde_6852749,
title = {Late vascular effects of whole brain X-irradiation in the mouse}
author = {Yoshii, Y, and Phillips, T L}
abstractNote = {The whole brains of mice were irradiated with 250kVp X-rays at 120 rads min/sup -1/ (1.6 mm Cu HVL, TSD 50 cm), and a histological study was carried out. The dose range of X-irradiation was from 1,300 to 2,500 rads, i.e., 1,300, 1,500, 1,750, 2,000, and 2,500 rads. Eighty-six mice were used for histological examination. For microscopic examination, the mice were killed at regular postirradiation intervals between 15 and 20, 31 and 40, 41 and 50, 51 and 60, 61 and 70, 71 and 80, 81 and 90, 139 and 177 weeks. The brains were removed immediately thereafter, fixed in Bouin's solution, and embedded in paraffin. A histological examination was performed by a morphometric estimation of vascular lesions, in which the degree of the damage to the arterial system was scored in whole serial brain section. Necrosis (encephalomalacia), atrophy, cell infiltration, and telangiectactic vascular change of the brain, caused as a result of the fibrinoid necrosis of the large arteries, were observed. Dose-dependent incidence of the fibrinoid necrosis increased between 41 and 87 weeks after irradiation. Mean score of fibrinoid necrosis increased dose dependently approximately 60 weeks after irradiation. It is suggested that scores of large vessel damage do relate to dose at 41 to 87 weeks, and can be used to quantify the vessel injury, and that fibrinoid necrosis of the large vessels may relate to the incidence of radionecrosis.}
doi = {10.1007/BF01405622}
journal = {Acta Neurochir.; (Austria)}
volume = {64:1-2}
journal type = {AC}
place = {Austria}
year = {1982}
month = {Jan}
}