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Studies on insulin secretion and insulin resistance in non-insulin-dependent diabetes in young Indians

Thesis/Dissertation:

Abstract

Patients with Non-insulin-dependent diabetes mellitus (NIDDM) have defects in insulin secretion and insulin action. In the discrete genetic syndrome of NIDDY (non-insulin-dependent diabetes in the young), the situation is less clear and these aspects is the subject of this thesis. This study included Indian pasients with three generation transmission of NIDDM via one parent. The insulin and C-peptide responses to oral and intravenous glucose in patients with NIDDY were studied. The insulin and glucose responses to non-glucose secretogogues glucagon, tolbutamide and arginine, in NIDDY were also investigated. The following aspects with regard to insulin resistance in NIDDY were examined: glucose and free fatty acid response to intravenous insulin administration, insulin binding to circulating erythrocytes and monocytes, /sup 125/I-insulin binding to the solubilized erythrocyte membrane receptor and /sup 125/I-insulin binding to fibroblasts in culture.
Authors:
Publication Date:
Jan 01, 1986
Product Type:
Thesis/Dissertation
Reference Number:
AIX-19-083621; EDB-88-157405
Resource Relation:
Other Information: Thesis (Ph.D.)
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DIABETES MELLITUS; INSULIN; LABELLED COMPOUNDS; SECRETION; ARGININE; BIOCHEMISTRY; CHROMIUM 51; EDTA; ERYTHROCYTES; EXPERIMENTAL DATA; FIBROBLASTS; GLUCOSE; HYDROCORTISONE; HYPERGLYCEMIA; IN VITRO; IN VIVO; INTRAVENOUS INJECTION; IODINE 125; LABELLING; MONOCYTES; ORAL ADMINISTRATION; PEPTIDES; RADIOIMMUNOASSAY; RECEPTORS; SOUTH AFRICA; ADRENAL HORMONES; AFRICA; ALDEHYDES; AMINO ACIDS; ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOHYDRATES; CARBOXYLIC ACIDS; CHELATING AGENTS; CHEMISTRY; CHROMIUM ISOTOPES; CONNECTIVE TISSUE CELLS; CORTICOSTEROIDS; DATA; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE DISEASES; EVEN-ODD NUCLEI; GLUCOCORTICOIDS; HEXOSES; HORMONES; HYDROXY COMPOUNDS; IMMUNOASSAY; IMMUNOLOGY; INFORMATION; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KETONES; LEUKOCYTES; MATERIALS; MEMBRANE PROTEINS; METABOLIC DISEASES; MONOSACCHARIDES; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PREGNANES; PROTEINS; RADIOASSAY; RADIOIMMUNOLOGY; RADIOISOTOPES; SACCHARIDES; SOMATIC CELLS; STEROIDS; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6840638
Research Organizations:
Natal Univ., Durban (South Africa)
Country of Origin:
South Africa
Language:
English
Availability:
Registrar, University of Natal, King George Avenue, Durban, 4001, South Africa.
Submitting Site:
INIS
Size:
Pages: 151
Announcement Date:
May 13, 2001

Thesis/Dissertation:

Citation Formats

Naidoo, C. Studies on insulin secretion and insulin resistance in non-insulin-dependent diabetes in young Indians. South Africa: N. p., 1986. Web.
Naidoo, C. Studies on insulin secretion and insulin resistance in non-insulin-dependent diabetes in young Indians. South Africa.
Naidoo, C. 1986. "Studies on insulin secretion and insulin resistance in non-insulin-dependent diabetes in young Indians." South Africa.
@misc{etde_6840638,
title = {Studies on insulin secretion and insulin resistance in non-insulin-dependent diabetes in young Indians}
author = {Naidoo, C}
abstractNote = {Patients with Non-insulin-dependent diabetes mellitus (NIDDM) have defects in insulin secretion and insulin action. In the discrete genetic syndrome of NIDDY (non-insulin-dependent diabetes in the young), the situation is less clear and these aspects is the subject of this thesis. This study included Indian pasients with three generation transmission of NIDDM via one parent. The insulin and C-peptide responses to oral and intravenous glucose in patients with NIDDY were studied. The insulin and glucose responses to non-glucose secretogogues glucagon, tolbutamide and arginine, in NIDDY were also investigated. The following aspects with regard to insulin resistance in NIDDY were examined: glucose and free fatty acid response to intravenous insulin administration, insulin binding to circulating erythrocytes and monocytes, /sup 125/I-insulin binding to the solubilized erythrocyte membrane receptor and /sup 125/I-insulin binding to fibroblasts in culture.}
place = {South Africa}
year = {1986}
month = {Jan}
}