Abstract
Two groups of rats were exposed to lead (0,2% lead acetate in drinking water) for periods of 21 days during different developmental phases. Lead exposure was initiated on day 1 and day 22 after birth, for rats in groups 1 and 2, respectively. Measurements of locomotor activity (LA) and (/sup 3/H)spiperone binding assays were performed on day 50 after birth. Lead exposure resulted in the potentiation of the LA effects of 5 mg/kg apomorphine without altering the LA effects of 50 mg/kg piribedil in group 1. Lead exposure resulted in an attenuation of the LA effects of apomorphine and piribedil in group 2. Lead exposure did not alter the K/sub D/ and B/sub max/ values of (/sup 3/H)spiperone in membranes prepared from the rat striatum or nucleus accumbens.
Citation Formats
Van Rooyen, J M, Offermeier, J, Brand, L, Botha, F, Rossouw, J, Lategan, A J, and Botes, M S.
Motor activity changes induced by sub-encephalopathic lead exposure during different developmental phases in rats.
South Africa: N. p.,
1988.
Web.
Van Rooyen, J M, Offermeier, J, Brand, L, Botha, F, Rossouw, J, Lategan, A J, & Botes, M S.
Motor activity changes induced by sub-encephalopathic lead exposure during different developmental phases in rats.
South Africa.
Van Rooyen, J M, Offermeier, J, Brand, L, Botha, F, Rossouw, J, Lategan, A J, and Botes, M S.
1988.
"Motor activity changes induced by sub-encephalopathic lead exposure during different developmental phases in rats."
South Africa.
@misc{etde_6836185,
title = {Motor activity changes induced by sub-encephalopathic lead exposure during different developmental phases in rats}
author = {Van Rooyen, J M, Offermeier, J, Brand, L, Botha, F, Rossouw, J, Lategan, A J, and Botes, M S}
abstractNote = {Two groups of rats were exposed to lead (0,2% lead acetate in drinking water) for periods of 21 days during different developmental phases. Lead exposure was initiated on day 1 and day 22 after birth, for rats in groups 1 and 2, respectively. Measurements of locomotor activity (LA) and (/sup 3/H)spiperone binding assays were performed on day 50 after birth. Lead exposure resulted in the potentiation of the LA effects of 5 mg/kg apomorphine without altering the LA effects of 50 mg/kg piribedil in group 1. Lead exposure resulted in an attenuation of the LA effects of apomorphine and piribedil in group 2. Lead exposure did not alter the K/sub D/ and B/sub max/ values of (/sup 3/H)spiperone in membranes prepared from the rat striatum or nucleus accumbens.}
journal = []
volume = {84:5}
journal type = {AC}
place = {South Africa}
year = {1988}
month = {May}
}
title = {Motor activity changes induced by sub-encephalopathic lead exposure during different developmental phases in rats}
author = {Van Rooyen, J M, Offermeier, J, Brand, L, Botha, F, Rossouw, J, Lategan, A J, and Botes, M S}
abstractNote = {Two groups of rats were exposed to lead (0,2% lead acetate in drinking water) for periods of 21 days during different developmental phases. Lead exposure was initiated on day 1 and day 22 after birth, for rats in groups 1 and 2, respectively. Measurements of locomotor activity (LA) and (/sup 3/H)spiperone binding assays were performed on day 50 after birth. Lead exposure resulted in the potentiation of the LA effects of 5 mg/kg apomorphine without altering the LA effects of 50 mg/kg piribedil in group 1. Lead exposure resulted in an attenuation of the LA effects of apomorphine and piribedil in group 2. Lead exposure did not alter the K/sub D/ and B/sub max/ values of (/sup 3/H)spiperone in membranes prepared from the rat striatum or nucleus accumbens.}
journal = []
volume = {84:5}
journal type = {AC}
place = {South Africa}
year = {1988}
month = {May}
}