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Lack of effect on the chromosomal non-disjunction in aged female mice after low dose x-irradiation

Journal Article:

Abstract

Karyotypes were determined in 1064 embryos of aged C57/BL mothers. The virgin female mice were irradiated with 0, 4, 8 or 16 R of X-rays, respectively, and placed with young untreated males 5 days after irradiation. 10.5-days old embryos were recovered from the uterus. Aneuploid embryos classified as alive (heart beats observed at the dissection) were 1 monosomic in the control group (496 embryos) and 2 trisomics in the irradiated group (568 embryos). The number of aneuploid embryos classified as dead was 4 trisomic cases in the control group and 3 trisomics in the irradiated group. The data indicate that trisomic embryos are not uncommon in the mouse but are eliminated in post-implantation death. In contrast to the results of Yamamoto et al. the present data do not demonstrate an increased frequency of chromosome abnormalities in embryos of aged mice X-irradiated before mating as compared to non-irradiated ones.
Authors:
Strausmanis, R; Hendrikson, I B; Holmberg, M; Roennbaeck, C [1] 
  1. Research Inst. of National Defence, Sundbyberg (Sweden). Dept. 4
Publication Date:
Feb 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-09-373547; EDB-78-105045
Resource Relation:
Journal Name: Mutat. Res.; (Netherlands); Journal Volume: 49:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANEUPLOIDY; RADIOINDUCTION; CHROMOSOMAL ABERRATIONS; AGE DEPENDENCE; EMBRYOS; GENETIC RADIATION EFFECTS; FEMALES; NON-DISJUNCTION; LOW DOSE IRRADIATION; MICE; MUTATION FREQUENCY; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MUTATIONS; PLOIDY; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6830522
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MUREA
Submitting Site:
INIS
Size:
Pages: 269-274
Announcement Date:
May 01, 1978

Journal Article:

Citation Formats

Strausmanis, R, Hendrikson, I B, Holmberg, M, and Roennbaeck, C. Lack of effect on the chromosomal non-disjunction in aged female mice after low dose x-irradiation. Netherlands: N. p., 1978. Web.
Strausmanis, R, Hendrikson, I B, Holmberg, M, & Roennbaeck, C. Lack of effect on the chromosomal non-disjunction in aged female mice after low dose x-irradiation. Netherlands.
Strausmanis, R, Hendrikson, I B, Holmberg, M, and Roennbaeck, C. 1978. "Lack of effect on the chromosomal non-disjunction in aged female mice after low dose x-irradiation." Netherlands.
@misc{etde_6830522,
title = {Lack of effect on the chromosomal non-disjunction in aged female mice after low dose x-irradiation}
author = {Strausmanis, R, Hendrikson, I B, Holmberg, M, and Roennbaeck, C}
abstractNote = {Karyotypes were determined in 1064 embryos of aged C57/BL mothers. The virgin female mice were irradiated with 0, 4, 8 or 16 R of X-rays, respectively, and placed with young untreated males 5 days after irradiation. 10.5-days old embryos were recovered from the uterus. Aneuploid embryos classified as alive (heart beats observed at the dissection) were 1 monosomic in the control group (496 embryos) and 2 trisomics in the irradiated group (568 embryos). The number of aneuploid embryos classified as dead was 4 trisomic cases in the control group and 3 trisomics in the irradiated group. The data indicate that trisomic embryos are not uncommon in the mouse but are eliminated in post-implantation death. In contrast to the results of Yamamoto et al. the present data do not demonstrate an increased frequency of chromosome abnormalities in embryos of aged mice X-irradiated before mating as compared to non-irradiated ones.}
journal = {Mutat. Res.; (Netherlands)}
volume = {49:2}
journal type = {AC}
place = {Netherlands}
year = {1978}
month = {Feb}
}