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Early changes of auditory brain stem evoked response after radiotherapy for nasopharyngeal carcinoma - a prospective study

Journal Article:

Abstract

A prospective study of the effect of radiotherapy for nasopharyngeal carcinoma on hearing was carried out on 49 patients who had pure tone, impedance audiometry and auditory brain stem evoked response (ABR) recordings before, immediately, three, six and 12 months after radiotherapy. Fourteen patients complained of intermittent tinnitus after radiotherapy. We found that 11 initially normal ears of nine patients developed a middle ear effusion, three to six months after radiotherapy. There was mixed sensorineural and conductive hearing impairment after radiotherapy. Persistent impairment of ABR was detected immediately after completion of radiotherapy. The waves I-III and I-V interpeak latency intervals were significantly prolonged one year after radiotherapy. The study shows that radiotherapy for nasopharyngeal carcinoma impairs hearing by acting on the middle ear, the cochlea and the brain stem auditory pathway. (Author).
Authors:
Lau, S K; Wei, W I; Sham, J S.T.; Choy, D T.K.; Hui, Y [1] 
  1. Queen Mary Hospital, Hong Kong (Hong Kong)
Publication Date:
Oct 01, 1992
Product Type:
Journal Article
Reference Number:
AIX-24-041681; EDB-93-071942
Resource Relation:
Journal Name: Journal of Laryngology and Otology; (United Kingdom); Journal Volume: 106:10
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; AUDITORY ORGANS; RADIOTHERAPY; PHARYNX; RADIATION INJURIES; SIDE EFFECTS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DIGESTIVE SYSTEM; INJURIES; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; RESPIRATORY SYSTEM; SENSE ORGANS; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
6823800
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0022-2151; CODEN: JLOTAX
Submitting Site:
GBN
Size:
Pages: 887-892
Announcement Date:

Journal Article:

Citation Formats

Lau, S K, Wei, W I, Sham, J S.T., Choy, D T.K., and Hui, Y. Early changes of auditory brain stem evoked response after radiotherapy for nasopharyngeal carcinoma - a prospective study. United Kingdom: N. p., 1992. Web.
Lau, S K, Wei, W I, Sham, J S.T., Choy, D T.K., & Hui, Y. Early changes of auditory brain stem evoked response after radiotherapy for nasopharyngeal carcinoma - a prospective study. United Kingdom.
Lau, S K, Wei, W I, Sham, J S.T., Choy, D T.K., and Hui, Y. 1992. "Early changes of auditory brain stem evoked response after radiotherapy for nasopharyngeal carcinoma - a prospective study." United Kingdom.
@misc{etde_6823800,
title = {Early changes of auditory brain stem evoked response after radiotherapy for nasopharyngeal carcinoma - a prospective study}
author = {Lau, S K, Wei, W I, Sham, J S.T., Choy, D T.K., and Hui, Y}
abstractNote = {A prospective study of the effect of radiotherapy for nasopharyngeal carcinoma on hearing was carried out on 49 patients who had pure tone, impedance audiometry and auditory brain stem evoked response (ABR) recordings before, immediately, three, six and 12 months after radiotherapy. Fourteen patients complained of intermittent tinnitus after radiotherapy. We found that 11 initially normal ears of nine patients developed a middle ear effusion, three to six months after radiotherapy. There was mixed sensorineural and conductive hearing impairment after radiotherapy. Persistent impairment of ABR was detected immediately after completion of radiotherapy. The waves I-III and I-V interpeak latency intervals were significantly prolonged one year after radiotherapy. The study shows that radiotherapy for nasopharyngeal carcinoma impairs hearing by acting on the middle ear, the cochlea and the brain stem auditory pathway. (Author).}
journal = {Journal of Laryngology and Otology; (United Kingdom)}
volume = {106:10}
journal type = {AC}
place = {United Kingdom}
year = {1992}
month = {Oct}
}