Abstract
NDV-induced interferon of peritoneal cells of irradiated (x-rays, 400 R) and control mice was investigated in vitro. Irradiation or treatment with hydroxyurea (10(-5) M) and mitomycin C (25 microng/ml) did not change interferon synthesis in spite of an 80 to 90% inhibition of 3H-thymidine incorporation. Increased doses of mitomycin C and treatment with actinomycin D and puromycin blocked interferon production. De novo interferon synthesis occurred in cells with damaged replicative activity of DNA caused by irradiation or by treatment with antimetabolites.
Citation Formats
Szolgay, E, and T'alas, M.
Interferon synthesis in mouse peritoneal cells damaged by x irradiation.
Switzerland: N. p.,
1976.
Web.
Szolgay, E, & T'alas, M.
Interferon synthesis in mouse peritoneal cells damaged by x irradiation.
Switzerland.
Szolgay, E, and T'alas, M.
1976.
"Interferon synthesis in mouse peritoneal cells damaged by x irradiation."
Switzerland.
@misc{etde_6817501,
title = {Interferon synthesis in mouse peritoneal cells damaged by x irradiation}
author = {Szolgay, E, and T'alas, M}
abstractNote = {NDV-induced interferon of peritoneal cells of irradiated (x-rays, 400 R) and control mice was investigated in vitro. Irradiation or treatment with hydroxyurea (10(-5) M) and mitomycin C (25 microng/ml) did not change interferon synthesis in spite of an 80 to 90% inhibition of 3H-thymidine incorporation. Increased doses of mitomycin C and treatment with actinomycin D and puromycin blocked interferon production. De novo interferon synthesis occurred in cells with damaged replicative activity of DNA caused by irradiation or by treatment with antimetabolites.}
journal = []
volume = {7:6}
journal type = {AC}
place = {Switzerland}
year = {1976}
month = {Jan}
}
title = {Interferon synthesis in mouse peritoneal cells damaged by x irradiation}
author = {Szolgay, E, and T'alas, M}
abstractNote = {NDV-induced interferon of peritoneal cells of irradiated (x-rays, 400 R) and control mice was investigated in vitro. Irradiation or treatment with hydroxyurea (10(-5) M) and mitomycin C (25 microng/ml) did not change interferon synthesis in spite of an 80 to 90% inhibition of 3H-thymidine incorporation. Increased doses of mitomycin C and treatment with actinomycin D and puromycin blocked interferon production. De novo interferon synthesis occurred in cells with damaged replicative activity of DNA caused by irradiation or by treatment with antimetabolites.}
journal = []
volume = {7:6}
journal type = {AC}
place = {Switzerland}
year = {1976}
month = {Jan}
}