You need JavaScript to view this

Interferon synthesis in mouse peritoneal cells damaged by x irradiation

Journal Article:

Abstract

NDV-induced interferon of peritoneal cells of irradiated (x-rays, 400 R) and control mice was investigated in vitro. Irradiation or treatment with hydroxyurea (10(-5) M) and mitomycin C (25 microng/ml) did not change interferon synthesis in spite of an 80 to 90% inhibition of 3H-thymidine incorporation. Increased doses of mitomycin C and treatment with actinomycin D and puromycin blocked interferon production. De novo interferon synthesis occurred in cells with damaged replicative activity of DNA caused by irradiation or by treatment with antimetabolites.
Publication Date:
Jan 01, 1976
Product Type:
Journal Article
Reference Number:
ERA-03-048819; EDB-78-098731
Resource Relation:
Journal Name: Intervirology; (Switzerland); Journal Volume: 7:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; INTERFERON; BIOSYNTHESIS; X RADIATION; BIOLOGICAL EFFECTS; AMINO ACIDS; ANIMAL CELLS; ANTIMETABOLITES; CELL CULTURES; DNA REPLICATION; HYDROXYUREA; IN VITRO; METABOLISM; MICE; MITOMYCIN; THYMIDINE; TRITIUM; AMIDES; ANIMALS; ANTIBIOTICS; ANTIMITOTIC DRUGS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; IONIZING RADIATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; NUCLEI; NUCLEIC ACID REPLICATION; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATIONS; RADIOISOTOPES; RIBOSIDES; RODENTS; SYNTHESIS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560114* - Radiation Effects on Biochemicals- In Animals- (-1987)
OSTI ID:
6817501
Research Organizations:
Hungarian Academy of Sciences, Budapest
Country of Origin:
Switzerland
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IVRYA
Submitting Site:
TIC
Size:
Pages: 338-345
Announcement Date:

Journal Article:

Citation Formats

Szolgay, E, and T'alas, M. Interferon synthesis in mouse peritoneal cells damaged by x irradiation. Switzerland: N. p., 1976. Web.
Szolgay, E, & T'alas, M. Interferon synthesis in mouse peritoneal cells damaged by x irradiation. Switzerland.
Szolgay, E, and T'alas, M. 1976. "Interferon synthesis in mouse peritoneal cells damaged by x irradiation." Switzerland.
@misc{etde_6817501,
title = {Interferon synthesis in mouse peritoneal cells damaged by x irradiation}
author = {Szolgay, E, and T'alas, M}
abstractNote = {NDV-induced interferon of peritoneal cells of irradiated (x-rays, 400 R) and control mice was investigated in vitro. Irradiation or treatment with hydroxyurea (10(-5) M) and mitomycin C (25 microng/ml) did not change interferon synthesis in spite of an 80 to 90% inhibition of 3H-thymidine incorporation. Increased doses of mitomycin C and treatment with actinomycin D and puromycin blocked interferon production. De novo interferon synthesis occurred in cells with damaged replicative activity of DNA caused by irradiation or by treatment with antimetabolites.}
journal = {Intervirology; (Switzerland)}
volume = {7:6}
journal type = {AC}
place = {Switzerland}
year = {1976}
month = {Jan}
}