You need JavaScript to view this

Oxygen effect and intracellular oxygen content (adaptation hypothesis)

Journal Article:

Abstract

Experimental data indicating that a radiomodifying action of hypoxia is dependent on the ''prehistory'' of the irradiated object are considered. This dependence manifests itself in a decreased protective action of acute hypoxia on the hypoxia-adapted objects. To explain this a hypothesis is proposed connecting a degree of cell radiosensitivity modification, determined by the oxygen effect, with the intracellular oxygen content. The latter, in accord with current ideas, is regulated by variations in the diffusion resistance to oxygen shown by the cytoplasmic membranes depending on the energy level of the cell and the degree of its oxygenation.
Authors:
Yarmonenko, S P; Ehpshtejn, I M [1] 
  1. Akademiya Meditsinskikh Nauk SSSR, Moscow. Onkologicheskij Tsentr
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-378984; EDB-78-098740
Resource Relation:
Journal Name: Radiobiologiya; (USSR); Journal Volume: 17:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; ANOXIA; RADIOSENSITIVITY EFFECTS; RADIOSENSITIVITY; BIOLOGICAL ADAPTATION; CELL MEMBRANES; OXIDATION; OXYGEN; QUANTITY RATIO; RESPONSE MODIFYING FACTORS; BIOLOGICAL EFFECTS; CELL CONSTITUENTS; CHEMICAL REACTIONS; CRYOGENIC FLUIDS; ELEMENTS; FLUIDS; MEMBRANES; NONMETALS; RADIATION EFFECTS; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
6817476
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: RADOA
Submitting Site:
INIS
Size:
Pages: 323-335
Announcement Date:

Journal Article:

Citation Formats

Yarmonenko, S P, and Ehpshtejn, I M. Oxygen effect and intracellular oxygen content (adaptation hypothesis). USSR: N. p., 1977. Web.
Yarmonenko, S P, & Ehpshtejn, I M. Oxygen effect and intracellular oxygen content (adaptation hypothesis). USSR.
Yarmonenko, S P, and Ehpshtejn, I M. 1977. "Oxygen effect and intracellular oxygen content (adaptation hypothesis)." USSR.
@misc{etde_6817476,
title = {Oxygen effect and intracellular oxygen content (adaptation hypothesis)}
author = {Yarmonenko, S P, and Ehpshtejn, I M}
abstractNote = {Experimental data indicating that a radiomodifying action of hypoxia is dependent on the ''prehistory'' of the irradiated object are considered. This dependence manifests itself in a decreased protective action of acute hypoxia on the hypoxia-adapted objects. To explain this a hypothesis is proposed connecting a degree of cell radiosensitivity modification, determined by the oxygen effect, with the intracellular oxygen content. The latter, in accord with current ideas, is regulated by variations in the diffusion resistance to oxygen shown by the cytoplasmic membranes depending on the energy level of the cell and the degree of its oxygenation.}
journal = {Radiobiologiya; (USSR)}
volume = {17:3}
journal type = {AC}
place = {USSR}
year = {1977}
month = {Jan}
}