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Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays

Abstract

Action of x radiation on the incorporation of /sup 3/H-thymidine into nuclei of cells of the regenerating liver of rats has been studied. A whole-body exposure of rats to 150 to 300 R has been found to inhibit /sup 3/H-thymidine uptake into DNA of S-cells of the regenerating liver, and this effect can be attributed to the inhibition of DNA synthesis rather than to changes in the concentration of a label in the intracellular pool of DNA precursors. In addition to the DNA synthesis decrease, inhibition of the label uptake into the pool is observed after doses of 600 to 1200 R. On the basis of the data obtained, a hypothesis is proposed that explains the mechanism of inhibition of DNA synthesis under the action of radiation.
Authors:
Aksenovich, T I; Polishchuk, A M [1] 
  1. AN SSSR, Novosibirsk. Inst. Tsitologii i Genetiki
Publication Date:
Jan 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-09-379005; EDB-78-098829
Resource Relation:
Journal Name: Radiobiologiya; (USSR); Journal Volume: 16:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BIOLOGICAL REGENERATION; DNA REPLICATION; BIOSYNTHESIS; INHIBITION; CELL NUCLEI; DNA; BIOLOGICAL RADIATION EFFECTS; LIVER; RATS; BIOCHEMICAL REACTION KINETICS; DOSE-RESPONSE RELATIONSHIPS; LABELLED COMPOUNDS; THYMIDINE; UPTAKE; WHOLE-BODY IRRADIATION; X RADIATION; ANIMALS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BODY; CELL CONSTITUENTS; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GLANDS; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; KINETICS; MAMMALS; NUCLEIC ACID REPLICATION; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; REACTION KINETICS; RECOVERY; RIBOSIDES; RODENTS; SYNTHESIS; VERTEBRATES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
6817186
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: RADOA
Submitting Site:
INIS
Size:
Pages: 11-15
Announcement Date:
Jul 01, 1978

Citation Formats

Aksenovich, T I, and Polishchuk, A M. Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays. USSR: N. p., 1976. Web.
Aksenovich, T I, & Polishchuk, A M. Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays. USSR.
Aksenovich, T I, and Polishchuk, A M. 1976. "Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays." USSR.
@misc{etde_6817186,
title = {Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays}
author = {Aksenovich, T I, and Polishchuk, A M}
abstractNote = {Action of x radiation on the incorporation of /sup 3/H-thymidine into nuclei of cells of the regenerating liver of rats has been studied. A whole-body exposure of rats to 150 to 300 R has been found to inhibit /sup 3/H-thymidine uptake into DNA of S-cells of the regenerating liver, and this effect can be attributed to the inhibition of DNA synthesis rather than to changes in the concentration of a label in the intracellular pool of DNA precursors. In addition to the DNA synthesis decrease, inhibition of the label uptake into the pool is observed after doses of 600 to 1200 R. On the basis of the data obtained, a hypothesis is proposed that explains the mechanism of inhibition of DNA synthesis under the action of radiation.}
journal = []
volume = {16:1}
journal type = {AC}
place = {USSR}
year = {1976}
month = {Jan}
}