Abstract
Action of x radiation on the incorporation of /sup 3/H-thymidine into nuclei of cells of the regenerating liver of rats has been studied. A whole-body exposure of rats to 150 to 300 R has been found to inhibit /sup 3/H-thymidine uptake into DNA of S-cells of the regenerating liver, and this effect can be attributed to the inhibition of DNA synthesis rather than to changes in the concentration of a label in the intracellular pool of DNA precursors. In addition to the DNA synthesis decrease, inhibition of the label uptake into the pool is observed after doses of 600 to 1200 R. On the basis of the data obtained, a hypothesis is proposed that explains the mechanism of inhibition of DNA synthesis under the action of radiation.
Citation Formats
Aksenovich, T I, and Polishchuk, A M.
Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays.
USSR: N. p.,
1976.
Web.
Aksenovich, T I, & Polishchuk, A M.
Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays.
USSR.
Aksenovich, T I, and Polishchuk, A M.
1976.
"Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays."
USSR.
@misc{etde_6817186,
title = {Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays}
author = {Aksenovich, T I, and Polishchuk, A M}
abstractNote = {Action of x radiation on the incorporation of /sup 3/H-thymidine into nuclei of cells of the regenerating liver of rats has been studied. A whole-body exposure of rats to 150 to 300 R has been found to inhibit /sup 3/H-thymidine uptake into DNA of S-cells of the regenerating liver, and this effect can be attributed to the inhibition of DNA synthesis rather than to changes in the concentration of a label in the intracellular pool of DNA precursors. In addition to the DNA synthesis decrease, inhibition of the label uptake into the pool is observed after doses of 600 to 1200 R. On the basis of the data obtained, a hypothesis is proposed that explains the mechanism of inhibition of DNA synthesis under the action of radiation.}
journal = []
volume = {16:1}
journal type = {AC}
place = {USSR}
year = {1976}
month = {Jan}
}
title = {Kinetics of /sup 3/H-thymidine incorporation into nuclei of cells of the regenerating liver of rats exposed to various doses of x rays}
author = {Aksenovich, T I, and Polishchuk, A M}
abstractNote = {Action of x radiation on the incorporation of /sup 3/H-thymidine into nuclei of cells of the regenerating liver of rats has been studied. A whole-body exposure of rats to 150 to 300 R has been found to inhibit /sup 3/H-thymidine uptake into DNA of S-cells of the regenerating liver, and this effect can be attributed to the inhibition of DNA synthesis rather than to changes in the concentration of a label in the intracellular pool of DNA precursors. In addition to the DNA synthesis decrease, inhibition of the label uptake into the pool is observed after doses of 600 to 1200 R. On the basis of the data obtained, a hypothesis is proposed that explains the mechanism of inhibition of DNA synthesis under the action of radiation.}
journal = []
volume = {16:1}
journal type = {AC}
place = {USSR}
year = {1976}
month = {Jan}
}