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Effect of mercaptoethylamine on DNA degradation in thermophilic bacteria Bac. stearothermophilus exposed to. gamma. -, UV-radiation or methylnitrosourea

Journal Article:

Abstract

The effect of mercaptoethylamine (MEA) on degradation of DNA in thermophilic bacteria Bac. stear. exposed to ..gamma..-, UV-rays or methylnitrosourea (MNU) was studied. Using centrifugation on alkaline and neutral sucrose gradients, it was shown that MEA inhibits the accumulation of breaks in the DNA of Bac. stear. It also lowers the level of DNA degradation in toluene-treated cells of Bac. stear. under the action of the intrinsic nuclease, reduces the activity of the endonuclease specific for apurinic DNA, as well as that of S/sub 1/-nuclease and DNase-I in vitro. The inhibition in the accumulation of DNA breaks is assumed to be due to a decrease of the endonuclease activity in the cells of thermophilic bacteria.
Publication Date:
Jul 01, 1984
Product Type:
Journal Article
Reference Number:
FRG-84-08362; EDB-84-111776
Resource Relation:
Journal Name: Radiat. Environ. Biophys.; (Germany, Federal Republic of); Journal Volume: 23:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BIOLOGICAL RADIATION EFFECTS; MEA; DNA; EFFICIENCY; ALKYLATING AGENTS; BACTERIA; CHEMICAL RADIATION EFFECTS; ENZYME ACTIVITY; EXTERNAL IRRADIATION; GAMMA RADIATION; INHIBITION; NUCLEASES; RADIOLYSIS; STRAND BREAKS; ULTRAVIOLET RADIATION; AMINES; BIOLOGICAL EFFECTS; CHEMICAL REACTIONS; CHEMISTRY; DECOMPOSITION; DRUGS; ELECTROMAGNETIC RADIATION; ENZYMES; ESTERASES; HYDROLASES; IONIZING RADIATIONS; IRRADIATION; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PHOSPHODIESTERASES; RADIATION CHEMISTRY; RADIATION EFFECTS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; THIOLS; 560131* - Radiation Effects on Microorganisms- Basic Studies- (-1987)
OSTI ID:
6816038
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: REBPA
Submitting Site:
HEDB
Size:
Pages: 223-233
Announcement Date:

Journal Article:

Citation Formats

Fomenko, L A, Kuznetsovea, E A, and Gaziev, A I. Effect of mercaptoethylamine on DNA degradation in thermophilic bacteria Bac. stearothermophilus exposed to. gamma. -, UV-radiation or methylnitrosourea. Germany: N. p., 1984. Web.
Fomenko, L A, Kuznetsovea, E A, & Gaziev, A I. Effect of mercaptoethylamine on DNA degradation in thermophilic bacteria Bac. stearothermophilus exposed to. gamma. -, UV-radiation or methylnitrosourea. Germany.
Fomenko, L A, Kuznetsovea, E A, and Gaziev, A I. 1984. "Effect of mercaptoethylamine on DNA degradation in thermophilic bacteria Bac. stearothermophilus exposed to. gamma. -, UV-radiation or methylnitrosourea." Germany.
@misc{etde_6816038,
title = {Effect of mercaptoethylamine on DNA degradation in thermophilic bacteria Bac. stearothermophilus exposed to. gamma. -, UV-radiation or methylnitrosourea}
author = {Fomenko, L A, Kuznetsovea, E A, and Gaziev, A I}
abstractNote = {The effect of mercaptoethylamine (MEA) on degradation of DNA in thermophilic bacteria Bac. stear. exposed to ..gamma..-, UV-rays or methylnitrosourea (MNU) was studied. Using centrifugation on alkaline and neutral sucrose gradients, it was shown that MEA inhibits the accumulation of breaks in the DNA of Bac. stear. It also lowers the level of DNA degradation in toluene-treated cells of Bac. stear. under the action of the intrinsic nuclease, reduces the activity of the endonuclease specific for apurinic DNA, as well as that of S/sub 1/-nuclease and DNase-I in vitro. The inhibition in the accumulation of DNA breaks is assumed to be due to a decrease of the endonuclease activity in the cells of thermophilic bacteria.}
journal = {Radiat. Environ. Biophys.; (Germany, Federal Republic of)}
volume = {23:3}
journal type = {AC}
place = {Germany}
year = {1984}
month = {Jul}
}