You need JavaScript to view this

Study of somatostatin in simple obesity

Journal Article:

Abstract

C-peptide, as a marker for pancreatic beta cells function, and somatostatin (SS) in plasma of obese males (n = 15) and a corresponding normal weight control subjects (n = 10) are studied. Fasting plasma SS and serum C-peptide are significantly higher in obese vs lean group. This can be explained by hypertrophy of both D- and B-cells of the pancreatic islets reported by other investigators. Post-prandial plasma SS is insignificantly increased in obese vs the control group whereas the increase in C-peptide levels is significant suggesting unequal response of B- and D-cells to meal in the obese group. It is concluded that circulating SS may play an important role in the development if obesity. Hyperinsulinaemia documented in obesity may be due to hypersecretion of insulin. That may contribute to increased somatomedin-C in obesity. (author).
Authors:
Abdel-Hafez, M A; El-Ghazaly, S; El-Feky, N A; Sayed, S N [1] 
  1. Cairo Univ. (Egypt)
Publication Date:
Feb 01, 1990
Product Type:
Journal Article
Reference Number:
AIX-21-058681; EDB-90-112444
Resource Relation:
Journal Name: Isotopenpraxis; (German Democratic Republic); Journal Volume: 26:2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; METABOLIC DISEASES; RADIOIMMUNOASSAY; INSULIN; MEN; PANCREAS; SOMATOSTATIN; ANIMALS; BIOASSAY; BODY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; ENDOCRINE GLANDS; GLANDS; HORMONES; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; MALES; MAMMALS; MAN; ORGANS; PEPTIDE HORMONES; PRIMATES; RADIOASSAY; RADIOIMMUNODETECTION; RADIOIMMUNOLOGY; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6809717
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0021-1915; CODEN: IPRXA
Submitting Site:
INIS
Size:
Pages: 70-72
Announcement Date:

Journal Article:

Citation Formats

Abdel-Hafez, M A, El-Ghazaly, S, El-Feky, N A, and Sayed, S N. Study of somatostatin in simple obesity. Germany: N. p., 1990. Web.
Abdel-Hafez, M A, El-Ghazaly, S, El-Feky, N A, & Sayed, S N. Study of somatostatin in simple obesity. Germany.
Abdel-Hafez, M A, El-Ghazaly, S, El-Feky, N A, and Sayed, S N. 1990. "Study of somatostatin in simple obesity." Germany.
@misc{etde_6809717,
title = {Study of somatostatin in simple obesity}
author = {Abdel-Hafez, M A, El-Ghazaly, S, El-Feky, N A, and Sayed, S N}
abstractNote = {C-peptide, as a marker for pancreatic beta cells function, and somatostatin (SS) in plasma of obese males (n = 15) and a corresponding normal weight control subjects (n = 10) are studied. Fasting plasma SS and serum C-peptide are significantly higher in obese vs lean group. This can be explained by hypertrophy of both D- and B-cells of the pancreatic islets reported by other investigators. Post-prandial plasma SS is insignificantly increased in obese vs the control group whereas the increase in C-peptide levels is significant suggesting unequal response of B- and D-cells to meal in the obese group. It is concluded that circulating SS may play an important role in the development if obesity. Hyperinsulinaemia documented in obesity may be due to hypersecretion of insulin. That may contribute to increased somatomedin-C in obesity. (author).}
journal = {Isotopenpraxis; (German Democratic Republic)}
volume = {26:2}
journal type = {AC}
place = {Germany}
year = {1990}
month = {Feb}
}