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Analysis of X-ray induced cell-cycle perturbations in mouse osteosarcoma cells: a two-signal cell-cycle model

Journal Article:

Abstract

The effects of X-irradiation on mouse osteosarcoma cells have been studied by time-lapse cinematography and the resulting pedigrees have been analysed statistically. It is shown that the irradiation treatment causes three types of cell kinetic lesions: cell death (disintegration), cell sterilization (failure to divide) and proliferation delay. The first two lesions are the most important with regard to survival of the irradiated cell in a clonal assay. Of these two lesions, sterilization appears to be highly correlated for sister cells, while this is not true for cell disintegration. This indicates that cell survival in a clonal assay may be a function of the ratio of the incidences of these two types of lesions. The X-ray-induced proliferation delay was studied in terms of intermitotic time distributions, mother-daughter correlation and sibling correlation in relation to the current cell-cycle phase at the time of treatment. This analysis shows that the effects of irradiation on these cell-cycle characteristics is highly cell-cycle-dependent. A qualitative model to account for the observations is presented.
Authors:
Meeteren, A van; Wijk, R van; [1]  Stap, J; Deys, B F [2] 
  1. Rijksuniversiteit Utrecht (Netherlands)
  2. Amsterdam Univ. (Netherlands)
Publication Date:
Mar 01, 1984
Product Type:
Journal Article
Reference Number:
AIX-15-055837; EDB-84-160158
Resource Relation:
Journal Name: Cell Tissue Kinet.; (United Kingdom); Journal Volume: 17:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CELL CYCLE; BIOLOGICAL RADIATION EFFECTS; OSTEOSARCOMAS; TUMOR CELLS; CELL CULTURES; CELL DIVISION; CELL PROLIFERATION; MICE; SURVIVAL CURVES; X RADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; DISEASES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; NEOPLASMS; RADIATION EFFECTS; RADIATIONS; RODENTS; SARCOMAS; SKELETAL DISEASES; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
6800089
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CTKIA
Submitting Site:
HEDB
Size:
Pages: 105-118
Announcement Date:

Journal Article:

Citation Formats

Meeteren, A van, Wijk, R van, Stap, J, and Deys, B F. Analysis of X-ray induced cell-cycle perturbations in mouse osteosarcoma cells: a two-signal cell-cycle model. United Kingdom: N. p., 1984. Web.
Meeteren, A van, Wijk, R van, Stap, J, & Deys, B F. Analysis of X-ray induced cell-cycle perturbations in mouse osteosarcoma cells: a two-signal cell-cycle model. United Kingdom.
Meeteren, A van, Wijk, R van, Stap, J, and Deys, B F. 1984. "Analysis of X-ray induced cell-cycle perturbations in mouse osteosarcoma cells: a two-signal cell-cycle model." United Kingdom.
@misc{etde_6800089,
title = {Analysis of X-ray induced cell-cycle perturbations in mouse osteosarcoma cells: a two-signal cell-cycle model}
author = {Meeteren, A van, Wijk, R van, Stap, J, and Deys, B F}
abstractNote = {The effects of X-irradiation on mouse osteosarcoma cells have been studied by time-lapse cinematography and the resulting pedigrees have been analysed statistically. It is shown that the irradiation treatment causes three types of cell kinetic lesions: cell death (disintegration), cell sterilization (failure to divide) and proliferation delay. The first two lesions are the most important with regard to survival of the irradiated cell in a clonal assay. Of these two lesions, sterilization appears to be highly correlated for sister cells, while this is not true for cell disintegration. This indicates that cell survival in a clonal assay may be a function of the ratio of the incidences of these two types of lesions. The X-ray-induced proliferation delay was studied in terms of intermitotic time distributions, mother-daughter correlation and sibling correlation in relation to the current cell-cycle phase at the time of treatment. This analysis shows that the effects of irradiation on these cell-cycle characteristics is highly cell-cycle-dependent. A qualitative model to account for the observations is presented.}
journal = {Cell Tissue Kinet.; (United Kingdom)}
volume = {17:2}
journal type = {AC}
place = {United Kingdom}
year = {1984}
month = {Mar}
}