You need JavaScript to view this

Study of dementia associated with alcoholism using N-isopropyl-p-(/sup 123/I) iodoamphetamine SPECT and 2 tesla magnetic resonance imaging

Journal Article:

Abstract

Using DSM-III-R criteria, five patients (ages 46 approx. 76 years) were diagosed as having DAA (dementia associated with alcoholism). An investigation was conducted using a ring-type single proton emission tomography system with N-isopropyl-p-(/sup 123/I) iodoamphetamine (IMP) and a magnetic resonance imaging system with a superconductive 2 tesla magnet. IMP uptake was measured 25 approx. 30 minutes after injection. Bilateral IMP uptake reduction was seen in all of the patients. The distribution of the reduced IMP uptake showed in the temporal region of all patients ; the frontal region in four of the patients and the occipital region in two of the patients. The reduction of IMP uptake was irregular, generally mild, and less severe than that of Alzheimer type dementia. The MRI study showed cortical atrophy, especially in the frontal and temporal areas, and also showed enlargement of the lateral and third ventricles. The reduced IMP uptake corresponded to cerebral atrophy and ventricular dilatation on the SE image (TR 3000, TE 60 or 82). These results indicate that the IMP SPECT and MRI studies are useful in examining DAA patients and in the classification of other types of dementia.
Publication Date:
Aug 01, 1988
Product Type:
Journal Article
Reference Number:
JPN-89-001124; EDB-89-022260
Resource Relation:
Journal Name: Nippon Gazo Igaku Zasshi; (Japan); Journal Volume: 7:2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; NMR IMAGING; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; IODINE 123; AMPHETAMINES; ATROPHY; ETHANOL; IMAGES; MENTAL DISORDERS; PATIENTS; ALCOHOLS; ANALEPTICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550602 - Medicine- External Radiation in Diagnostics- (1980-)
OSTI ID:
6799428
Research Organizations:
South Japan Health Science Center (Fujimoto Hospital), Miyazaki (Japan)
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NGIZE
Submitting Site:
JPN
Size:
Pages: 93-99
Announcement Date:
Dec 01, 1988

Journal Article:

Citation Formats

Fujimoto, Toshiro, Uchida, Tsunehisa, and Yokoyama, Yoji and others. Study of dementia associated with alcoholism using N-isopropyl-p-(/sup 123/I) iodoamphetamine SPECT and 2 tesla magnetic resonance imaging. Japan: N. p., 1988. Web.
Fujimoto, Toshiro, Uchida, Tsunehisa, & Yokoyama, Yoji and others. Study of dementia associated with alcoholism using N-isopropyl-p-(/sup 123/I) iodoamphetamine SPECT and 2 tesla magnetic resonance imaging. Japan.
Fujimoto, Toshiro, Uchida, Tsunehisa, and Yokoyama, Yoji and others. 1988. "Study of dementia associated with alcoholism using N-isopropyl-p-(/sup 123/I) iodoamphetamine SPECT and 2 tesla magnetic resonance imaging." Japan.
@misc{etde_6799428,
title = {Study of dementia associated with alcoholism using N-isopropyl-p-(/sup 123/I) iodoamphetamine SPECT and 2 tesla magnetic resonance imaging}
author = {Fujimoto, Toshiro, Uchida, Tsunehisa, and Yokoyama, Yoji and others}
abstractNote = {Using DSM-III-R criteria, five patients (ages 46 approx. 76 years) were diagosed as having DAA (dementia associated with alcoholism). An investigation was conducted using a ring-type single proton emission tomography system with N-isopropyl-p-(/sup 123/I) iodoamphetamine (IMP) and a magnetic resonance imaging system with a superconductive 2 tesla magnet. IMP uptake was measured 25 approx. 30 minutes after injection. Bilateral IMP uptake reduction was seen in all of the patients. The distribution of the reduced IMP uptake showed in the temporal region of all patients ; the frontal region in four of the patients and the occipital region in two of the patients. The reduction of IMP uptake was irregular, generally mild, and less severe than that of Alzheimer type dementia. The MRI study showed cortical atrophy, especially in the frontal and temporal areas, and also showed enlargement of the lateral and third ventricles. The reduced IMP uptake corresponded to cerebral atrophy and ventricular dilatation on the SE image (TR 3000, TE 60 or 82). These results indicate that the IMP SPECT and MRI studies are useful in examining DAA patients and in the classification of other types of dementia.}
journal = {Nippon Gazo Igaku Zasshi; (Japan)}
volume = {7:2}
journal type = {AC}
place = {Japan}
year = {1988}
month = {Aug}
}