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Monoclonal antibodies in oncology. Review article

Abstract

Monoclonal antibodies (MCAs) can be used to differentiate between normal and neoplastic cells and thus exploited for diagnostic and, ultimately, therapeutic gain. The evidence for the existence of human tumour antigens is reviewed. Several areas of diagnosis are already benefiting from the application of the monoclonal technology. Immunohistology can help the pathologist with difficult diagnostic problems. New classifications of lymphoma and leukaemia can be based on specific surface molecules. Similarly, the detection of shed tumour antigens is already established as part of the routine assessment of many patients with common solid tumours. Isotopically labeled monoclonal antibodies have been used to localise primary and metastatic tumours. The use of antibodies in this way is not only a promising diagnostic tool but also the first step in studying the possibility of arming antibodies to provide therapeutic agents. Such trials are currently in progress. 69 refs.; 7 figs.; 3 tabs.
Publication Date:
May 01, 1986
Product Type:
Journal Article
Reference Number:
AIX-18-028058; EDB-87-058369
Resource Relation:
Journal Name: Radiother. Oncol.; (Netherlands); Journal Volume: 6:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIGENS; MONOCLONAL ANTIBODIES; DIAGNOSTIC USES; THERAPEUTIC USES; METASTASES; NEOPLASMS; RADIOIMMUNOTHERAPY; TUMOR CELLS; ANIMAL CELLS; ANTIBODIES; DISEASES; IMMUNOLOGY; MEDICINE; NUCLEAR MEDICINE; RADIOIMMUNOLOGY; RADIOLOGY; RADIOTHERAPY; THERAPY; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
OSTI ID:
6796125
Research Organizations:
Medical Research Council, Cambridge, UK. Ludwig Institute for Cancer Research
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: RAOND
Submitting Site:
INIS
Size:
Pages: 1-14
Announcement Date:
Mar 01, 1987

Citation Formats

Chan, S Y.T., and Sikora, K. Monoclonal antibodies in oncology. Review article. Netherlands: N. p., 1986. Web. doi:10.1016/S0167-8140(86)80105-0.
Chan, S Y.T., & Sikora, K. Monoclonal antibodies in oncology. Review article. Netherlands. https://doi.org/10.1016/S0167-8140(86)80105-0
Chan, S Y.T., and Sikora, K. 1986. "Monoclonal antibodies in oncology. Review article." Netherlands. https://doi.org/10.1016/S0167-8140(86)80105-0.
@misc{etde_6796125,
title = {Monoclonal antibodies in oncology. Review article}
author = {Chan, S Y.T., and Sikora, K}
abstractNote = {Monoclonal antibodies (MCAs) can be used to differentiate between normal and neoplastic cells and thus exploited for diagnostic and, ultimately, therapeutic gain. The evidence for the existence of human tumour antigens is reviewed. Several areas of diagnosis are already benefiting from the application of the monoclonal technology. Immunohistology can help the pathologist with difficult diagnostic problems. New classifications of lymphoma and leukaemia can be based on specific surface molecules. Similarly, the detection of shed tumour antigens is already established as part of the routine assessment of many patients with common solid tumours. Isotopically labeled monoclonal antibodies have been used to localise primary and metastatic tumours. The use of antibodies in this way is not only a promising diagnostic tool but also the first step in studying the possibility of arming antibodies to provide therapeutic agents. Such trials are currently in progress. 69 refs.; 7 figs.; 3 tabs.}
doi = {10.1016/S0167-8140(86)80105-0}
journal = {Radiother. Oncol.; (Netherlands)}
volume = {6:1}
journal type = {AC}
place = {Netherlands}
year = {1986}
month = {May}
}