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Heme synthesis in the lead-intoxicated mouse embryo

Journal Article:

Abstract

Incorporation of /sup 55/Fe and of (/sup 14/C) glycine was studied in control embryos and mothers and in those which had received lead in the diet from day 7 of pregnancy. Incorporation of Fe into heme of embryonic liver which increases markedly for controls on day 17 of pregnancy was depressed greatly and showed no such increase in lead-intoxicated embryos. These embryos were retarded in growth but had normal heme concentrations in body and liver. Incorporation of glycine into embryonic heme and proteins was not affected. Data on incorporation in the mothers are also presented. It is thought that the impaired synthesis of heme in lead-intoxicated embryos limits their body growth during the late phase of pregnancy.
Publication Date:
Feb 01, 1978
Product Type:
Journal Article
Reference Number:
ERA-03-051278; EDB-78-105187
Resource Relation:
Journal Name: Toxicology; (Netherlands); Journal Volume: 9:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; HEME; BIOSYNTHESIS; LEAD; BIOLOGICAL EFFECTS; ONTOGENESIS; CARBON 14; EMBRYOS; GLYCINE; GROWTH; IRON 55; LABELLING; LIVER; MICE; PREGNANCY; PROTEINS; TOXICITY; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CARBOXYLIC ACIDS; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; GLANDS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; INTERMEDIATE MASS NUCLEI; IRON ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAMMALS; METALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PIGMENTS; PORPHYRINS; RADIOISOTOPES; RODENTS; SYNTHESIS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550500 - Metabolism; 550501 - Metabolism- Tracer Techniques
OSTI ID:
6786919
Research Organizations:
C.E.N., Mol, Belgium
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: TXCYA
Submitting Site:
TIC
Size:
Pages: 173-179
Announcement Date:

Journal Article:

Citation Formats

Gerber, G B, and Maes, J. Heme synthesis in the lead-intoxicated mouse embryo. Netherlands: N. p., 1978. Web.
Gerber, G B, & Maes, J. Heme synthesis in the lead-intoxicated mouse embryo. Netherlands.
Gerber, G B, and Maes, J. 1978. "Heme synthesis in the lead-intoxicated mouse embryo." Netherlands.
@misc{etde_6786919,
title = {Heme synthesis in the lead-intoxicated mouse embryo}
author = {Gerber, G B, and Maes, J}
abstractNote = {Incorporation of /sup 55/Fe and of (/sup 14/C) glycine was studied in control embryos and mothers and in those which had received lead in the diet from day 7 of pregnancy. Incorporation of Fe into heme of embryonic liver which increases markedly for controls on day 17 of pregnancy was depressed greatly and showed no such increase in lead-intoxicated embryos. These embryos were retarded in growth but had normal heme concentrations in body and liver. Incorporation of glycine into embryonic heme and proteins was not affected. Data on incorporation in the mothers are also presented. It is thought that the impaired synthesis of heme in lead-intoxicated embryos limits their body growth during the late phase of pregnancy.}
journal = {Toxicology; (Netherlands)}
volume = {9:2}
journal type = {AC}
place = {Netherlands}
year = {1978}
month = {Feb}
}